Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?

• Published in: Nutrients Vol. 11; no. 11; p. 2704
• Main Authors: Izquierdo, Andrea G., Crujeiras, Ana B., Casanueva, Felipe F., Carreira, Marcos C.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.11.2019; MDPI
• Subjects: Adiposity - drug effects; Anti-Obesity Agents - therapeutic use; Blood-Brain Barrier - metabolism; Brain - drug effects; Brain - metabolism; Brain - physiopathology; Capillary Permeability; Endocrinology; Endoplasmic reticulum; Feeding Behavior - drug effects; food intake; Homeostasis; Hormones; Humans; hypothalamus; Laboratories; leptin; Leptin - metabolism; Metabolism; Nervous system; Obesity; Obesity - drug therapy; Obesity - metabolism; Obesity - physiopathology; Obesity - psychology; Proteins; Review; Signal Transduction; transportation; Weight control; Weight Gain - drug effects; Spain; blood brain barrier; leptin resistance; leptin; obesity

Leptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity. However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin...