Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors. One important extrinsic factor is the extracellular matrix, the non-cellular compo...

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Published inFrontiers in oncology Vol. 9; p. 1482
Main Authors Elgundi, Zehra, Papanicolaou, Michael, Major, Gretel, Cox, Thomas R, Melrose, James, Whitelock, John M, Farrugia, Brooke L
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.01.2020
Subjects
cancer metastasis
heparan sulfate proteoglycan
heparanase
Oncology
perlecan
therapeutic
therapeutic
perlecan
heparanase
heparan sulfate proteoglycan
cancer metastasis
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Abstract Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors. One important extrinsic factor is the extracellular matrix, the non-cellular component of tissues. Heparan sulfate proteoglycans (HSPGs) are constituents of the extracellular matrix, and through their heparan sulfate chains and protein core, modulate multiple events that occur during the metastatic cascade. This review will provide an overview of the role of the extracellular matrix in the events that occur during cancer metastasis, primarily focusing on perlecan. Perlecan, a basement membrane HSPG is a key component of the vascular extracellular matrix and is commonly associated with events that occur during the metastatic cascade. Its contradictory role in these events will be discussed and we will highlight the recent advances in cancer therapies that target HSPGs and their modifying enzymes.
AbstractList Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors. One important extrinsic factor is the extracellular matrix, the non-cellular component of tissues. Heparan sulfate proteoglycans (HSPGs) are constituents of the extracellular matrix, and through their heparan sulfate chains and protein core, modulate multiple events that occur during the metastatic cascade. This review will provide an overview of the role of the extracellular matrix in the events that occur during cancer metastasis, primarily focusing on perlecan. Perlecan, a basement membrane HSPG is a key component of the vascular extracellular matrix and is commonly associated with events that occur during the metastatic cascade. Its contradictory role in these events will be discussed and we will highlight the recent advances in cancer therapies that target HSPGs and their modifying enzymes.
Author Farrugia, Brooke L
Cox, Thomas R
Melrose, James
Whitelock, John M
Elgundi, Zehra
Major, Gretel
Papanicolaou, Michael
AuthorAffiliation 2 The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, UNSW Sydney , Darlinghurst, NSW , Australia
4 St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney , Sydney, NSW , Australia
3 School of Life Sciences, University of Technology Sydney , Sydney, NSW , Australia
1 Graduate School of Biomedical Engineering, UNSW Sydney , Sydney, NSW , Australia
6 Department of Biomedical Engineering, Melbourne School of Engineering, The University of Melbourne , Melbourne, VIC , Australia
5 Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney , St Leonards, NSW , Australia
AuthorAffiliation_xml – name: 2 The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, UNSW Sydney , Darlinghurst, NSW , Australia
– name: 3 School of Life Sciences, University of Technology Sydney , Sydney, NSW , Australia
– name: 6 Department of Biomedical Engineering, Melbourne School of Engineering, The University of Melbourne , Melbourne, VIC , Australia
– name: 1 Graduate School of Biomedical Engineering, UNSW Sydney , Sydney, NSW , Australia
– name: 5 Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney , St Leonards, NSW , Australia
– name: 4 St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney , Sydney, NSW , Australia
Author_xml – sequence: 1
  givenname: Zehra
  surname: Elgundi
  fullname: Elgundi, Zehra
  organization: Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia
– sequence: 2
  givenname: Michael
  surname: Papanicolaou
  fullname: Papanicolaou, Michael
  organization: School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia
– sequence: 3
  givenname: Gretel
  surname: Major
  fullname: Major, Gretel
  organization: The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, UNSW Sydney, Darlinghurst, NSW, Australia
– sequence: 4
  givenname: Thomas R
  surname: Cox
  fullname: Cox, Thomas R
  organization: St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia
– sequence: 5
  givenname: James
  surname: Melrose
  fullname: Melrose, James
  organization: Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia
– sequence: 6
  givenname: John M
  surname: Whitelock
  fullname: Whitelock, John M
  organization: Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia
– sequence: 7
  givenname: Brooke L
  surname: Farrugia
  fullname: Farrugia, Brooke L
  organization: Department of Biomedical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32010611$$D View this record in MEDLINE/PubMed
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Copyright Copyright © 2020 Elgundi, Papanicolaou, Major, Cox, Melrose, Whitelock and Farrugia.
Copyright © 2020 Elgundi, Papanicolaou, Major, Cox, Melrose, Whitelock and Farrugia. 2020 Elgundi, Papanicolaou, Major, Cox, Melrose, Whitelock and Farrugia
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Keywords therapeutic
perlecan
heparanase
heparan sulfate proteoglycan
cancer metastasis
Language English
License Copyright © 2020 Elgundi, Papanicolaou, Major, Cox, Melrose, Whitelock and Farrugia.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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content type line 23
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Reviewed by: Mary C. (Cindy) Farach-Carson, University of Texas Health Science Center at Houston, United States; Maurizio Mongiat, Centro di Riferimento Oncologico di Aviano (IRCCS), Italy
Edited by: Cinzia Lanzi, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy
This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978720/
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  year: 2020
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PublicationTitle Frontiers in oncology
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Snippet Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially...
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StartPage 1482
SubjectTerms cancer metastasis
heparan sulfate proteoglycan
heparanase
Oncology
perlecan
therapeutic
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Title Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan
URI https://www.ncbi.nlm.nih.gov/pubmed/32010611
https://search.proquest.com/docview/2350341075
https://pubmed.ncbi.nlm.nih.gov/PMC6978720
https://doaj.org/article/3fe847808b0b437497e4b77815dbe1d9
Volume 9
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