New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling - Salomatina, Oksana V.; Kornienko, Tatyana E.; Zakharenko, Alexandra L.; Komarova, Nina I.; Achara, Chigozie; Reynisson, Jóhannes; Salakhutdinov, Nariman F.; Lavrik, Olga I.; Volcho, Konstantin P. (Molecules (Basel, Switzerland), 2024)
Keywords: Acids; Amino acids; cancer; Chromatography; Cytotoxicity; Deoxycholic acid; DNA; DNA damage; Enzymes; Etoposide; Ligands; oxirane; Radiotherapy; Steroids; TDP1 inhibitor; TDP2 inhibitor; thiols; Germany; Russia; oxirane; TDP1 inhibitor; TDP2 inhibitor; molecular modeling; tumor; cancer; deoxycholic acid; thiols