Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications

Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes. Based on their endogenous ligands, purinergic receptors are classified into P1 or adenosine,...

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Published inMolecular Imaging Vol. 19; p. 1536012120927609
Main Authors Zarrinmayeh, Hamideh, Territo, Paul R.
Format Book Review Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 2020
Sage Publications Ltd
Subjects
Adenosine
Adenosine receptors
Adenosine triphosphate
Astrocytes
ATP
Brain
Brain injury
Cell activation
Central nervous system
Disorders
Head injuries
Inflammation
Ligands
Nervous system
Neuroimaging
Positron emission
Positron emission tomography
Purine P2X receptors
Purine P2Y receptors
Purine receptors
Radioactive tracers
Radioisotopes
Receptors
Review
Tomography
Uridine
purinergic receptors
PET ligands
biology
neuroinflammation
central nervous system
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Abstract Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes. Based on their endogenous ligands, purinergic receptors are classified into P1 or adenosine, P2X and P2Y receptors. During brain injury or under pathological conditions, rapid diffusion of extracellular adenosine triphosphate (ATP) or uridine triphosphate (UTP) from the damaged cells, promote microglial activation that result in the changes in expression of several of these receptors in the brain. Imaging of the purinergic receptors with selective Positron Emission Tomography (PET) radioligands has advanced our understanding of the functional roles of some of these receptors in healthy and diseased brains. In this review, we have accumulated a list of currently available PET radioligands of the purinergic receptors that are used to elucidate the receptor functions and participations in CNS disorders. We have also reviewed receptors lacking radiotracer, laying the foundation for future discoveries of novel PET radioligands to reveal these receptors roles in CNS disorders.
AbstractList Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes. Based on their endogenous ligands, purinergic receptors are classified into P1 or adenosine, P2X and P2Y receptors. During brain injury or under pathological conditions, rapid diffusion of extracellular adenosine triphosphate (ATP) or uridine triphosphate (UTP) from the damaged cells, promote microglial activation that result in the changes in expression of several of these receptors in the brain. Imaging of the purinergic receptors with selective Positron Emission Tomography (PET) radioligands has advanced our understanding of the functional roles of some of these receptors in healthy and diseased brains. In this review, we have accumulated a list of currently available PET radioligands of the purinergic receptors that are used to elucidate the receptor functions and participations in CNS disorders. We have also reviewed receptors lacking radiotracer, laying the foundation for future discoveries of novel PET radioligands to reveal these receptors roles in CNS disorders.
Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes. Based on their endogenous ligands, purinergic receptors are classified into P1 or adenosine, P2X and P2Y receptors. During brain injury or under pathological conditions, rapid diffusion of extracellular adenosine triphosphate (ATP) or uridine triphosphate (UTP) from the damaged cells, promote microglial activation that result in the changes in expression of several of these receptors in the brain. Imaging of the purinergic receptors with selective Positron Emission Tomography (PET) radioligands has advanced our understanding of the functional roles of some of these receptors in healthy and diseased brains. In this review, we have accumulated a list of currently available PET radioligands of the purinergic receptors that are used to elucidate the receptor functions and participations in CNS disorders. We have also reviewed receptors lacking radiotracer, laying the foundation for future discoveries of novel PET radioligands to reveal these receptors roles in CNS disorders.
Author Zarrinmayeh, Hamideh
Territo, Paul R.
AuthorAffiliation 1 Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
AuthorAffiliation_xml – name: 1 Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
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  surname: Territo
  fullname: Territo, Paul R.
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DWQXO
FR3
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PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c505t-34288641d2d2bd655572297b7e68e02579fa5102f76cc0391fdf882ba8d7d4b43
IEDL.DBID RPM
ISSN 1535-3508
IngestDate Tue Oct 22 15:07:04 EDT 2024
Tue Sep 17 21:27:51 EDT 2024
Fri Aug 16 22:46:11 EDT 2024
Thu Oct 10 16:35:20 EDT 2024
Wed Oct 23 14:19:55 EDT 2024
Tue Jul 16 20:38:11 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
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Keywords purinergic receptors
PET ligands
biology
neuroinflammation
central nervous system
Language English
License This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
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content type line 23
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ORCID 0000-0002-3604-4924
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PMID 32539522
PQID 2473713461
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PublicationCentury 2000
PublicationDate 2020-00-00
PublicationDateYYYYMMDD 2020-01-01
PublicationDate_xml – year: 2020
  text: 2020-00-00
PublicationDecade 2020
PublicationPlace Los Angeles, CA
PublicationPlace_xml – name: Los Angeles, CA
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PublicationTitle Molecular Imaging
PublicationYear 2020
Publisher SAGE Publications
Sage Publications Ltd
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Snippet Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate...
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StartPage 1536012120927609
SubjectTerms Adenosine
Adenosine receptors
Adenosine triphosphate
Astrocytes
ATP
Brain
Brain injury
Cell activation
Central nervous system
Disorders
Head injuries
Inflammation
Ligands
Nervous system
Neuroimaging
Positron emission
Positron emission tomography
Purine P2X receptors
Purine P2Y receptors
Purine receptors
Radioactive tracers
Radioisotopes
Receptors
Review
Tomography
Uridine
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Title Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications
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