Residual Convolutional Neural Network for the Determination of IDH Status in Low- and High-Grade Gliomas from MR Imaging

• Published in: Clinical cancer research Vol. 24; no. 5; pp. 1073 - 1081
• Main Authors: Chang, Ken, Bai, Harrison X., Zhou, Hao, Su, Chang, Bi, Wenya Linda, Agbodza, Ena, Kavouridis, Vasileios K., Senders, Joeky T., Boaro, Alessandro, Beers, Andrew, Zhang, Biqi, Capellini, Alexandra, Liao, Weihua, Shen, Qin, Li, Xuejun, Xiao, Bo, Cryan, Jane, Ramkissoon, Shakti, Ramkissoon, Lori, Ligon, Keith, Wen, Patrick Y., Bindra, Ranjit S., Woo, John, Arnaout, Omar, Gerstner, Elizabeth R., Zhang, Paul J., Rosen, Bruce R., Yang, Li, Huang, Raymond Y., Kalpathy-Cramer, Jayashree
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 01.03.2018
• Subjects: Adult; Aged; Aged, 80 and over; Archives & records; Artificial neural networks; Brain - diagnostic imaging; Brain - pathology; Brain - surgery; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - genetics; Brain Neoplasms - mortality; Brain Neoplasms - surgery; Cancer; Colleges & universities; Datasets as Topic; Decision making; Experimental design; Female; Genotypes; Glioma; Glioma - diagnostic imaging; Glioma - genetics; Glioma - mortality; Glioma - surgery; Humans; Image acquisition; Image Processing, Computer-Assisted - methods; Isocitrate dehydrogenase; Isocitrate Dehydrogenase - genetics; Machine learning; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Mathematical models; Middle Aged; Model accuracy; Mutation; Neoplasm Grading; Neural networks; Neural Networks, Computer; Patients; Prediction models; Predictive Value of Tests; Preoperative Period; Retrospective Studies; Shearing; Training; Translations; Young Adult; Zooming

Purpose: Isocitrate dehydrogenase (IDH) mutations in glioma patients confer longer survival and may guide treatment decision making. We aimed to predict the IDH status of gliomas from MR imaging by applying a residual convolutional neural network to preoperative radiographic data. Experimental Desig...