Modulation of the tumor microenvironment by microbiota-derived short-chain fatty acids: impact in colorectal cancer therapy

• Published in: International journal of molecular sciences Vol. 24; no. 6; pp. 1 - 19
• Main Authors: Gomes, Sara, Rodrigues, Ana Catarina, Pazienza, Valerio, Preto, Ana
• Format: Journal Article
• Language: English
• Published: Switzerland Multidisciplinary Digital Publishing Institute (MDPI) 07.03.2023; MDPI AG; MDPI
• Subjects: Angiogenesis; Antimitotic agents; Antineoplastic agents; Butyrates - pharmacology; Cancer; Cancer therapies; Chemotherapy; Colorectal cancer; Colorectal cancer (CRC); Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - metabolism; Drugs; Fatty acids; Fatty Acids, Volatile - metabolism; Gastrointestinal Microbiome; Health aspects; Humans; Immunotherapy; Inflammation; Kinases; Metabolites; Metastasis; Microbiota; Microbiota (Symbiotic organisms); Monoclonal antibodies; Mutation; Radiation therapy; Review; Science & Technology; Therapy; Tumor Microenvironment; Tumors; Vascular endothelial growth factor; colorectal cancer (CRC); tumor microenvironment; short-chain fatty acids (SCFAs); therapy

Finding new therapeutic approaches towards colorectal cancer (CRC) is of increased relevance, as CRC is one of the most common cancers worldwide. CRC standard therapy includes surgery, chemotherapy, and radiotherapy, which may be used alone or in combination. The reported side effects and acquired r...