Anti-Acne Effects of Cembrene Diterpenoids from the Cultured Soft Coral Sinularia flexibilis

• Published in: Marine drugs Vol. 18; no. 10; p. 487
• Main Authors: Chen, Li-Wei, Chung, Hsuan-Lien, Wang, Ching-Chiung, Su, Jui-Hsin, Chen, Yu-Ju, Lee, Chia-Jung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.09.2020; MDPI
• Subjects: Acids; Acne; Acne Vulgaris - drug therapy; Acne Vulgaris - microbiology; Acne Vulgaris - pathology; adolescents; adults; Animals; Anthozoa - metabolism; anti-inflammatory activity; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Antibiotics; Cell growth; Cell proliferation; Cells; cembrene diterpenoids; corals; Cutibacterium acnes; Cytokines; Cytotoxicity; Diterpenes; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Drug resistance; drugs; Ears; Edema; Edema - drug therapy; Edema - microbiology; HaCaT Cells; Humans; hyperkeratosis; Inflammation; inhibitory concentration 50; Kinases; Lipopolysaccharides; Male; MAP kinase; MAPK; Marine invertebrates; Marine organisms; Mice; Microbiota; microorganisms; Nitric oxide; Nitric Oxide - metabolism; Nitric-oxide synthase; Nonsteroidal anti-inflammatory drugs; population; Proliferation; Propionibacterium acnes - isolation & purification; Protein kinase; Proteins; Puberty; Rats; Rats, Wistar; RAW 264.7 Cells; sebum; Sinularia; Sinularia flexibilis; Skin; Skin diseases; Testosterone; Cutibacterium acnes; acne; MAPK; inflammation; cembrene diterpenoids; Sinularia flexibilis

Acne is a skin disease common in adolescents and increasingly common in the adult population. The major pathologic events of acne vulgaris include increased sebum production, retention hyperkeratosis, carrying commensal skin microbiota, and inflammation. In recent years, more than 10,000 compounds h...