Recent Advances in ROS-Sensitive Nano-Formulations for Atherosclerosis Applications

Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery, and imaging. The intensified interest in ROS-sensitive formulations is attributed to their unique self-adaptive properties, involving the main...

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Published inPharmaceutics Vol. 13; no. 9; p. 1452
Main Authors Ji, Hao, Peng, Renyi, Jin, Libo, Ma, Jiahui, Yang, Qinsi, Sun, Da, Wu, Wei
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.09.2021
MDPI
Subjects
Amino acids
Atherosclerosis
Bioavailability
Cardiovascular disease
Drug dosages
imaging
Inflammation
Lipids
Metabolism
Metabolites
Mortality
nano-formulations
Nanoparticles
Physiology
Polyethylene glycol
polymer
Polypeptides
reactive oxygen species
Review
Selenium
atherosclerosis
polymer
nano-formulations
imaging
reactive oxygen species
Online AccessGet full text

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Abstract Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery, and imaging. The intensified interest in ROS-sensitive formulations is attributed to their unique self-adaptive properties, involving the main molecular mechanisms of solubility switch and degradation under the pathological ROS differences in atherosclerosis. This review outlines the advances in the use of ROS-sensitive formulations in atherosclerosis applications during the past decade, especially highlighting the general design requirements in relation to biomedical functional performance.
AbstractList Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery, and imaging. The intensified interest in ROS-sensitive formulations is attributed to their unique self-adaptive properties, involving the main molecular mechanisms of solubility switch and degradation under the pathological ROS differences in atherosclerosis. This review outlines the advances in the use of ROS-sensitive formulations in atherosclerosis applications during the past decade, especially highlighting the general design requirements in relation to biomedical functional performance.
Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery, and imaging. The intensified interest in ROS-sensitive formulations is attributed to their unique self-adaptive properties, involving the main molecular mechanisms of solubility switch and degradation under the pathological ROS differences in atherosclerosis. This review outlines the advances in the use of ROS-sensitive formulations in atherosclerosis applications during the past decade, especially highlighting the general design requirements in relation to biomedical functional performance.Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery, and imaging. The intensified interest in ROS-sensitive formulations is attributed to their unique self-adaptive properties, involving the main molecular mechanisms of solubility switch and degradation under the pathological ROS differences in atherosclerosis. This review outlines the advances in the use of ROS-sensitive formulations in atherosclerosis applications during the past decade, especially highlighting the general design requirements in relation to biomedical functional performance.
Author Jin, Libo
Sun, Da
Ji, Hao
Wu, Wei
Peng, Renyi
Yang, Qinsi
Ma, Jiahui
AuthorAffiliation 2 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; yangqs@wiucas.cn
1 Institute of Life Sciences & Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Wenzhou University, Wenzhou 325035, China; 20180031@wzu.edu.cn (H.J.); 20170032@wzu.edu.cn (R.P.); 20160121@wzu.edu.cn (L.J.); 204513344001@wzu.edu.cn (J.M.)
3 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China
AuthorAffiliation_xml – name: 1 Institute of Life Sciences & Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Wenzhou University, Wenzhou 325035, China; 20180031@wzu.edu.cn (H.J.); 20170032@wzu.edu.cn (R.P.); 20160121@wzu.edu.cn (L.J.); 204513344001@wzu.edu.cn (J.M.)
– name: 2 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; yangqs@wiucas.cn
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Keywords atherosclerosis
polymer
nano-formulations
imaging
reactive oxygen species
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Snippet Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery,...
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SubjectTerms Amino acids
Atherosclerosis
Bioavailability
Cardiovascular disease
Drug dosages
imaging
Inflammation
Lipids
Metabolism
Metabolites
Mortality
nano-formulations
Nanoparticles
Physiology
Polyethylene glycol
polymer
Polypeptides
reactive oxygen species
Review
Selenium
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Title Recent Advances in ROS-Sensitive Nano-Formulations for Atherosclerosis Applications
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