Identification of a cell-penetrating peptide applicable to a protein-based transcription activator-like effector expression system for cell engineering

• Published in: Biomaterials Vol. 173; pp. 11 - 21
• Main Authors: Takashina, Tomoki, Koyama, Takayoshi, Nohara, Satoshi, Hasegawa, Masakatsu, Ishiguro, Akira, Iijima, Kenta, Lu, Jun, Shimura, Mari, Okamura, Tadashi, Sakuma, Tetsushi, Yamamoto, Takashi, Ishizaka, Yukihito
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2018
• Subjects: Artificial transcription factor; Cell-penetrating peptide (CPP); Induced pluripotent stem cell (iPSC); Mouse embryonic fibroblast (MEF); Transcription activator-like effector (TALE); Mouse embryonic fibroblast (MEF); Induced pluripotent stem cell (iPSC); Cell-penetrating peptide (CPP); Artificial transcription factor; Transcription activator-like effector (TALE)

Cellular reprogramming is a promising technology in regenerative medicine, but most studies have been performed by using expression vectors. For future clinical applications, it is necessary to establish a system in which cell engineering can be manipulated without any risk of damaging the genome. H...