Age-Related Neurodegenerative Diseases: A Stem Cell’s Perspective

Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and a concomitant decline in neurological function. Examples of this type of clinical condition are Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and Amyotrophic L...

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Published inCells (Basel, Switzerland) Vol. 14; no. 5; p. 347
Main Authors Calvo, Belén, Schembri-Wismayer, Pierre, Durán-Alonso, María Beatriz
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2025
MDPI
Subjects
Age
Aging
Aging - pathology
Alzheimer's disease
Amyotrophic lateral sclerosis
Analysis
Animal cognition
Animals
Anxiety
Cell culture
cell models
Cognitive ability
Development and progression
Drug development
Enzymes
Homeostasis
Humans
Huntingtons disease
MicroRNAs
Nervous system diseases
neural stem cells
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - therapy
neurodegenerative disorders
Neurogenesis
Neurons
Parkinson's disease
Peptides
pluripotent stem cells
Proteins
Review
Secretome
Stem cells
Stem Cells - metabolism
stem-cell-based therapy
neurogenesis
cell models
pluripotent stem cells
neurodegenerative disorders
stem-cell-based therapy
neural stem cells
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Abstract Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and a concomitant decline in neurological function. Examples of this type of clinical condition are Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and Amyotrophic Lateral Sclerosis. Age has been identified as a major risk in the etiology of these disorders, which explains their increased incidence in developed countries. Unfortunately, despite continued and intensive efforts, no cure has yet been found for any of these diseases; reliable markers that allow for an early diagnosis of the disease and the identification of key molecular events leading to disease onset and progression are lacking. Altered adult neurogenesis appears to precede the appearance of severe symptoms. Given the scarcity of human samples and the considerable differences with model species, increasingly complex human stem-cell-based models are being developed. These are shedding light on the molecular alterations that contribute to disease development, facilitating the identification of new clinical targets and providing a screening platform for the testing of candidate drugs. Moreover, the secretome and other promising features of these cell types are being explored, to use them as replacement cells of high plasticity or as co-adjuvant therapy in combinatorial treatments.
AbstractList Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and a concomitant decline in neurological function. Examples of this type of clinical condition are Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and Amyotrophic Lateral Sclerosis. Age has been identified as a major risk in the etiology of these disorders, which explains their increased incidence in developed countries. Unfortunately, despite continued and intensive efforts, no cure has yet been found for any of these diseases; reliable markers that allow for an early diagnosis of the disease and the identification of key molecular events leading to disease onset and progression are lacking. Altered adult neurogenesis appears to precede the appearance of severe symptoms. Given the scarcity of human samples and the considerable differences with model species, increasingly complex human stem-cell-based models are being developed. These are shedding light on the molecular alterations that contribute to disease development, facilitating the identification of new clinical targets and providing a screening platform for the testing of candidate drugs. Moreover, the secretome and other promising features of these cell types are being explored, to use them as replacement cells of high plasticity or as co-adjuvant therapy in combinatorial treatments.
Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and a concomitant decline in neurological function. Examples of this type of clinical condition are Alzheimer's Disease, Parkinson's Disease, Huntington's Disease and Amyotrophic Lateral Sclerosis. Age has been identified as a major risk in the etiology of these disorders, which explains their increased incidence in developed countries. Unfortunately, despite continued and intensive efforts, no cure has yet been found for any of these diseases; reliable markers that allow for an early diagnosis of the disease and the identification of key molecular events leading to disease onset and progression are lacking. Altered adult neurogenesis appears to precede the appearance of severe symptoms. Given the scarcity of human samples and the considerable differences with model species, increasingly complex human stem-cell-based models are being developed. These are shedding light on the molecular alterations that contribute to disease development, facilitating the identification of new clinical targets and providing a screening platform for the testing of candidate drugs. Moreover, the secretome and other promising features of these cell types are being explored, to use them as replacement cells of high plasticity or as co-adjuvant therapy in combinatorial treatments.Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and a concomitant decline in neurological function. Examples of this type of clinical condition are Alzheimer's Disease, Parkinson's Disease, Huntington's Disease and Amyotrophic Lateral Sclerosis. Age has been identified as a major risk in the etiology of these disorders, which explains their increased incidence in developed countries. Unfortunately, despite continued and intensive efforts, no cure has yet been found for any of these diseases; reliable markers that allow for an early diagnosis of the disease and the identification of key molecular events leading to disease onset and progression are lacking. Altered adult neurogenesis appears to precede the appearance of severe symptoms. Given the scarcity of human samples and the considerable differences with model species, increasingly complex human stem-cell-based models are being developed. These are shedding light on the molecular alterations that contribute to disease development, facilitating the identification of new clinical targets and providing a screening platform for the testing of candidate drugs. Moreover, the secretome and other promising features of these cell types are being explored, to use them as replacement cells of high plasticity or as co-adjuvant therapy in combinatorial treatments.
Audience Academic
Author Calvo, Belén
Schembri-Wismayer, Pierre
Durán-Alonso, María Beatriz
AuthorAffiliation 1 Faculty of Health Sciences, Catholic University of Ávila, 05005 Ávila, Spain; belen.calvo@ucavila.es
2 Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta; pierre.schembri-wismayer@um.edu.mt
3 Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain
AuthorAffiliation_xml – name: 2 Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta; pierre.schembri-wismayer@um.edu.mt
– name: 3 Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain
– name: 1 Faculty of Health Sciences, Catholic University of Ávila, 05005 Ávila, Spain; belen.calvo@ucavila.es
Author_xml – sequence: 1
  givenname: Belén
  orcidid: 0000-0003-1415-1363
  surname: Calvo
  fullname: Calvo, Belén
– sequence: 2
  givenname: Pierre
  orcidid: 0000-0001-6340-9063
  surname: Schembri-Wismayer
  fullname: Schembri-Wismayer, Pierre
– sequence: 3
  givenname: María Beatriz
  orcidid: 0000-0001-7784-0591
  surname: Durán-Alonso
  fullname: Durán-Alonso, María Beatriz
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40072076$$D View this record in MEDLINE/PubMed
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Keywords neurogenesis
cell models
pluripotent stem cells
neurodegenerative disorders
stem-cell-based therapy
neural stem cells
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Snippet Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and a concomitant decline in...
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SubjectTerms Age
Aging
Aging - pathology
Alzheimer's disease
Amyotrophic lateral sclerosis
Analysis
Animal cognition
Animals
Anxiety
Cell culture
cell models
Cognitive ability
Development and progression
Drug development
Enzymes
Homeostasis
Humans
Huntingtons disease
MicroRNAs
Nervous system diseases
neural stem cells
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - therapy
neurodegenerative disorders
Neurogenesis
Neurons
Parkinson's disease
Peptides
pluripotent stem cells
Proteins
Review
Secretome
Stem cells
Stem Cells - metabolism
stem-cell-based therapy
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Title Age-Related Neurodegenerative Diseases: A Stem Cell’s Perspective
URI https://www.ncbi.nlm.nih.gov/pubmed/40072076
https://www.proquest.com/docview/3176299411
https://www.proquest.com/docview/3176347688
https://pubmed.ncbi.nlm.nih.gov/PMC11898746
https://doaj.org/article/dc13cc189d0649ffa5ae6781fe9926e9
Volume 14
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