Chaperonin-mediated protein folding: using a central cavity to kinetically assist polypeptide chain folding

• Published in: Quarterly reviews of biophysics Vol. 42; no. 2; pp. 83 - 116
• Main Authors: Horwich, Arthur L., Fenton, Wayne A.
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.05.2009
• Subjects: Animals; Chaperonins - metabolism; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Peptides - chemistry; Peptides - metabolism; Polypeptides; Protein Folding; Thermodynamics

The chaperonin ring assembly GroEL provides kinetic assistance to protein folding in the cell by binding non-native protein in the hydrophobic central cavity of an open ring and subsequently, upon binding ATP and the co-chaperonin GroES to the same ring, releasing polypeptide into a now hydrophilic...