The miR-15/107 Group of MicroRNA Genes: Evolutionary Biology, Cellular Functions, and Roles in Human Diseases

• Published in: Journal of molecular biology Vol. 402; no. 3; pp. 491 - 509
• Main Authors: Finnerty, John R., Wang, Wang-Xia, Hébert, Sébastien S., Wilfred, Bernard R., Mao, Guogen, Nelson, Peter T.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 24.09.2010
• Subjects: Alzheimer's disease; Animals; brain; Cell Proliferation; Cerebral Cortex - metabolism; Evolution, Molecular; Gene Expression Regulation; Heart Diseases - genetics; Humans; MicroRNAs - physiology; miR-103; miR-107; miR-16; Neoplasms - genetics; Neovascularization, Pathologic - genetics; Neovascularization, Physiologic - genetics; neurodegeneration; Neurodegenerative Diseases - genetics; Oligonucleotide Array Sequence Analysis; GRN; CLL; AD; neurodegeneration; PANK; brain; PKAN; miR-107; miR-103; miR-16; CoA; miRNA; TBI

The miR-15/107 group of microRNA (miRNA) gene is increasingly appreciated to serve key functions in humans. These miRNAs regulate gene expression involved in cell division, metabolism, stress response, and angiogenesis in vertebrate species. The miR-15/107 group has also been implicated in human can...