Role of nerve growth factor-tyrosine kinase receptor A signaling in paclitaxel-induced peripheral neuropathy in rats

• Published in: Biochemical and biophysical research communications Vol. 444; no. 3; pp. 415 - 419
• Main Authors: Nakahashi, Yusuke, Kamiya, Yoshinori, Funakoshi, Kengo, Miyazaki, Tomoyuki, Uchimoto, Kazuhiro, Tojo, Kentaro, Ogawa, Kenichi, Fukuoka, Tetsuo, Goto, Takahisa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.02.2014
• Subjects: Animals; Base Sequence; Brain-Derived Neurotrophic Factor - metabolism; DNA Primers; Dorsal root ganglia; Male; Nerve growth factor; Nerve Growth Factor - metabolism; Paclitaxel; Paclitaxel - pharmacology; Peripheral Nervous System Diseases - chemically induced; Peripheral Nervous System Diseases - enzymology; Peripheral Nervous System Diseases - metabolism; Peripheral neuropathy; Rats; Rats, Sprague-Dawley; Receptor, trkA - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Spinal dorsal horn; Tyrosine kinase receptor A; NEDD4-2; p75NTR; DH; BDNF; Nerve growth factor; I.P; NGF; Peripheral neuropathy; I.T; Tyrosine kinase receptor A; SNL; Spinal dorsal horn; TrkB; TrkA; Dorsal root ganglia; Paclitaxel; DRG; qPCR; SKIN; SN

•Paclitaxel administration induced painful neuropathy in rats.•NGF and trkA levels are increased in the DRG of paclitaxel-treated rats.•NGF and trkA increases are independent from Transcription or degradation.•Intrathecal administration of k252a partially attenuated pain behaviors. The mechanisms un...