Slow Progression of Poorly Differentiated Gastric Carcinoma Associated with Epstein-Barr Virus Infection: 12-year Follow-up

Epstein-Barr virus (EBV)-associated gastric carcinoma accounts for nearly 10% of all gastric carcinomas and has distinct demographic, clinical and pathological features compared with EBV-negative gastric carcinoma. We herein report the case of a patient with EBV-associated gastric carcinoma followed...

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Published inInternal Medicine Vol. 54; no. 12; pp. 1505 - 1508
Main Authors Yoza, Rina, Ueda, Yoshihide, Sakuma, Yojiro, Minami, Naoki, Takahashi, Ken, Minamiguchi, Sachiko, Haga, Hironori, Chiba, Tsutomu
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2015
Subjects
Disease Progression
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - diagnostic imaging
Follow-Up Studies
Gastrectomy
gastric carcinoma
Gastroscopy
Hematemesis - etiology
Herpesvirus 4, Human - isolation & purification
Humans
Male
Middle Aged
natural history
Prognosis
Stomach Neoplasms - complications
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - pathology
Stomach Neoplasms - virology
Tomography, X-Ray Computed
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Abstract Epstein-Barr virus (EBV)-associated gastric carcinoma accounts for nearly 10% of all gastric carcinomas and has distinct demographic, clinical and pathological features compared with EBV-negative gastric carcinoma. We herein report the case of a patient with EBV-associated gastric carcinoma followed up for 12 years during the natural course of the disease. The appearance of the tumor on gastroscopy and computed tomography gradually changed, and the size of the lesion increased very slowly during the 12 years, without metastasis. The present case indicates that some EBV-associated gastric carcinomas progress very slowly.
AbstractList Epstein-Barr virus (EBV)-associated gastric carcinoma accounts for nearly 10% of all gastric carcinomas and has distinct demographic, clinical and pathological features compared with EBV-negative gastric carcinoma. We herein report the case of a patient with EBV-associated gastric carcinoma followed up for 12 years during the natural course of the disease. The appearance of the tumor on gastroscopy and computed tomography gradually changed, and the size of the lesion increased very slowly during the 12 years, without metastasis. The present case indicates that some EBV-associated gastric carcinomas progress very slowly.
Author Yoza, Rina
Takahashi, Ken
Minami, Naoki
Sakuma, Yojiro
Minamiguchi, Sachiko
Haga, Hironori
Chiba, Tsutomu
Ueda, Yoshihide
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10.1200/JCO.2004.08.061
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10.1111/j.1349-7006.2007.00674.x
10.1158/0008-5472.CAN-11-3919
10.1038/bjc.2011.215
10.1111/j.1440-1746.2009.05775.x
10.1007/s10120-011-0041-5
10.1053/j.gastro.2009.05.001
10.1038/nature13480
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SubjectTerms Disease Progression
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - diagnostic imaging
Follow-Up Studies
Gastrectomy
gastric carcinoma
Gastroscopy
Hematemesis - etiology
Herpesvirus 4, Human - isolation & purification
Humans
Male
Middle Aged
natural history
Prognosis
Stomach Neoplasms - complications
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - pathology
Stomach Neoplasms - virology
Tomography, X-Ray Computed
Title Slow Progression of Poorly Differentiated Gastric Carcinoma Associated with Epstein-Barr Virus Infection: 12-year Follow-up
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