Interindividual variability and lateralization of μ-opioid receptors in the human brain

Alterations in the brain’s μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably in healthy individuals. Multiple epidemiological factors have been proposed to influence the MOR system, but due to small sample s...

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Published in	NeuroImage (Orlando, Fla.) Vol. 217; p. 116922
Main Authors	Kantonen, Tatu, Karjalainen, Tomi, Isojärvi, Janne, Nuutila, Pirjo, Tuisku, Jouni, Rinne, Juha, Hietala, Jarmo, Kaasinen, Valtteri, Kalliokoski, Kari, Scheinin, Harry, Hirvonen, Jussi, Vehtari, Aki, Nummenmaa, Lauri
Format	Journal Article
Language	English
Published	United States Elsevier Inc 15.08.2020 Elsevier Limited Elsevier
Subjects	[11C]carfentanil Adult Age Ageing Aging - physiology Amygdala Analgesics, Opioid Binding sites Body Mass Index Brain Chemistry - physiology Brain lateralization Brain research Chronic pain Endogenous opioids Epidemiology Female Fentanyl - analogs & derivatives Functional Laterality - physiology Hemispheric laterality Humans Individuality Male Mental disorders Middle Aged Narcotics Nucleus accumbens Opioid receptors Pain Positron emission tomography Radiopharmaceuticals Receptors, Opioid, mu - metabolism Researchers Scanners Sex Characteristics Smoking Specialization Studies Thalamus Young Adult μ-Opioid receptors Endogenous opioids μ-Opioid receptors [11C]carfentanil Brain lateralization Positron emission tomography Ageing [C]carfentanil
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Abstract	Alterations in the brain’s μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably in healthy individuals. Multiple epidemiological factors have been proposed to influence the MOR system, but due to small sample sizes the magnitude of their influence remains inconclusive. We compiled [11C]carfentanil positron emission tomography scans from 204 individuals with no neurologic or psychiatric disorders, and estimated the effects of sex, age, body mass index (BMI) and smoking on [11C]carfentanil binding potential using between-subject regression analysis. We also examined hemispheric differences in MOR availability. Older age was associated with increase in MOR availability in frontotemporal areas but decrease in amygdala, thalamus, and nucleus accumbens. The age-dependent increase was stronger in males. MOR availability was globally lowered in smokers but independent of BMI. Finally, MOR availability was higher in the right versus the left hemisphere. The presently observed variation in MOR availability may explain why some individuals are prone to develop MOR-linked pathological states, such as chronic pain or psychiatric disorders. Lateralized MOR system may reflect hemispheric work specialization in central emotion and pain processes. •Sex, age and smoking have regionally specific influence on human μ-opioid receptor (MOR) availability in the brain.•MOR availabilities have regional asymmetries between the two hemispheres, right hemisphere being more abundant in MORs.•Variability in MOR system may explain why some individuals are vulnerable to chronic pain and neuropsychiatric disorders.
AbstractList	Alterations in the brain’s μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably in healthy individuals. Multiple epidemiological factors have been proposed to influence the MOR system, but due to small sample sizes the magnitude of their influence remains inconclusive. We compiled [11C]carfentanil positron emission tomography scans from 204 individuals with no neurologic or psychiatric disorders, and estimated the effects of sex, age, body mass index (BMI) and smoking on [11C]carfentanil binding potential using between-subject regression analysis. We also examined hemispheric differences in MOR availability. Older age was associated with increase in MOR availability in frontotemporal areas but decrease in amygdala, thalamus, and nucleus accumbens. The age-dependent increase was stronger in males. MOR availability was globally lowered in smokers but independent of BMI. Finally, MOR availability was higher in the right versus the left hemisphere. The presently observed variation in MOR availability may explain why some individuals are prone to develop MOR-linked pathological states, such as chronic pain or psychiatric disorders. Lateralized MOR system may reflect hemispheric work specialization in central emotion and pain processes. Alterations in the brain’s μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably in healthy individuals. Multiple epidemiological factors have been proposed to influence the MOR system, but due to small sample sizes the magnitude of their influence remains inconclusive. We compiled [11C]carfentanil positron emission tomography scans from 204 individuals with no neurologic or psychiatric disorders, and estimated the effects of sex, age, body mass index (BMI) and smoking on [11C]carfentanil binding potential using between-subject regression analysis. We also examined hemispheric differences in MOR availability. Older age was associated with increase in MOR availability in frontotemporal areas but decrease in amygdala, thalamus, and nucleus accumbens. The age-dependent increase was stronger in males. MOR availability was globally lowered in smokers but independent of BMI. Finally, MOR availability was higher in the right versus the left hemisphere. The presently observed variation in MOR availability may explain why some individuals are prone to develop MOR-linked pathological states, such as chronic pain or psychiatric disorders. Lateralized MOR system may reflect hemispheric work specialization in central emotion and pain processes. •Sex, age and smoking have regionally specific influence on human μ-opioid receptor (MOR) availability in the brain.•MOR availabilities have regional asymmetries between the two hemispheres, right hemisphere being more abundant in MORs.•Variability in MOR system may explain why some individuals are vulnerable to chronic pain and neuropsychiatric disorders. Alterations in the brain's μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably in healthy individuals. Multiple epidemiological factors have been proposed to influence the MOR system, but due to small sample sizes the magnitude of their influence remains inconclusive. We compiled [ C]carfentanil positron emission tomography scans from 204 individuals with no neurologic or psychiatric disorders, and estimated the effects of sex, age, body mass index (BMI) and smoking on [ C]carfentanil binding potential using between-subject regression analysis. We also examined hemispheric differences in MOR availability. Older age was associated with increase in MOR availability in frontotemporal areas but decrease in amygdala, thalamus, and nucleus accumbens. The age-dependent increase was stronger in males. MOR availability was globally lowered in smokers but independent of BMI. Finally, MOR availability was higher in the right versus the left hemisphere. The presently observed variation in MOR availability may explain why some individuals are prone to develop MOR-linked pathological states, such as chronic pain or psychiatric disorders. Lateralized MOR system may reflect hemispheric work specialization in central emotion and pain processes. Alterations in the brain's μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably in healthy individuals. Multiple epidemiological factors have been proposed to influence the MOR system, but due to small sample sizes the magnitude of their influence remains inconclusive. We compiled [11C]carfentanil positron emission tomography scans from 204 individuals with no neurologic or psychiatric disorders, and estimated the effects of sex, age, body mass index (BMI) and smoking on [11C]carfentanil binding potential using between-subject regression analysis. We also examined hemispheric differences in MOR availability. Older age was associated with increase in MOR availability in frontotemporal areas but decrease in amygdala, thalamus, and nucleus accumbens. The age-dependent increase was stronger in males. MOR availability was globally lowered in smokers but independent of BMI. Finally, MOR availability was higher in the right versus the left hemisphere. The presently observed variation in MOR availability may explain why some individuals are prone to develop MOR-linked pathological states, such as chronic pain or psychiatric disorders. Lateralized MOR system may reflect hemispheric work specialization in central emotion and pain processes.Alterations in the brain's μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably in healthy individuals. Multiple epidemiological factors have been proposed to influence the MOR system, but due to small sample sizes the magnitude of their influence remains inconclusive. We compiled [11C]carfentanil positron emission tomography scans from 204 individuals with no neurologic or psychiatric disorders, and estimated the effects of sex, age, body mass index (BMI) and smoking on [11C]carfentanil binding potential using between-subject regression analysis. We also examined hemispheric differences in MOR availability. Older age was associated with increase in MOR availability in frontotemporal areas but decrease in amygdala, thalamus, and nucleus accumbens. The age-dependent increase was stronger in males. MOR availability was globally lowered in smokers but independent of BMI. Finally, MOR availability was higher in the right versus the left hemisphere. The presently observed variation in MOR availability may explain why some individuals are prone to develop MOR-linked pathological states, such as chronic pain or psychiatric disorders. Lateralized MOR system may reflect hemispheric work specialization in central emotion and pain processes.
ArticleNumber	116922
Author	Hirvonen, Jussi Kaasinen, Valtteri Hietala, Jarmo Scheinin, Harry Nuutila, Pirjo Vehtari, Aki Tuisku, Jouni Kalliokoski, Kari Nummenmaa, Lauri Rinne, Juha Isojärvi, Janne Kantonen, Tatu Karjalainen, Tomi
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Cites_doi	10.1212/WNL.48.5.1196 10.1163/000579511X596624 10.1002/ana.410150302 10.1038/nrn3475 10.1093/cercor/bht204 10.1073/pnas.1602413113 10.1093/bja/aet123 10.1007/s00381-002-0604-1 10.1016/0006-8993(81)90634-X 10.3389/fninf.2020.00003 10.1001/archpsyc.63.11.1199 10.1016/j.biopsych.2006.06.021 10.1111/adb.12022 10.1016/j.pneurobio.2012.06.010 10.1016/j.neubiorev.2017.01.039 10.1016/j.neurobiolaging.2017.05.006 10.1038/s41380-018-0117-2 10.1152/jn.00166.2009 10.1038/s41562-017-0189-z 10.1016/j.neuroimage.2008.08.032 10.1146/annurev-neuro-080317-061522 10.1523/JNEUROSCI.2849-07.2007 10.1093/cercor/bhl041 10.1016/0306-4522(89)90407-7 10.1016/j.ejpain.2003.11.017 10.1016/S0169-328X(97)00041-7 10.1016/j.tins.2012.11.002 10.1016/j.psyneuen.2011.03.019 10.1162/08997660260293292 10.1038/sj.jcbfm.9600493 10.1177/0956797611417632 10.1126/science.aal3618 10.1038/jcbfm.1989.59 10.1111/bph.13812 10.1038/sj.npp.1301238 10.1523/JNEUROSCI.4744-14.2015 10.1097/AJP.0b013e3181850df6 10.1176/ajp.156.6.842 10.1038/s41467-019-12366-4 10.1016/j.conb.2004.05.005 10.1152/physrev.00018.2016 10.1111/rssa.12378 10.1016/0304-3940(90)90491-Q 10.1111/j.1745-6924.2009.01130.x 10.1046/j.1467-789x.2001.00031.x 10.1016/j.neuron.2005.05.005 10.1038/npp.2017.148 10.1073/pnas.1018699108 10.1523/JNEUROSCI.5223-05.2006 10.1038/nrn.2016.167 10.1046/j.1460-9568.2003.02502.x 10.1371/journal.pone.0184923 10.1016/0165-3806(87)90082-4 10.1006/nimg.1996.0066 10.1016/0006-8993(95)00333-L 10.1017/S146114571200017X 10.1210/jc.2015-1783 10.1006/nimg.2001.0786 10.1093/brain/awm255 10.1038/jcbfm.2014.117 10.1016/0006-8993(90)91301-V 10.1038/npp.2016.265 10.1038/nature10194 10.1007/s11065-014-9268-3 10.1111/j.1530-0277.2011.01565.x 10.1007/s00702-004-0239-3 10.1126/science.1060952
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Copyright	2020 The Author(s) Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. 2020. The Author(s)
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Keywords	Endogenous opioids μ-Opioid receptors [11C]carfentanil Brain lateralization Positron emission tomography Ageing [C]carfentanil
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PublicationYear	2020
Publisher	Elsevier Inc Elsevier Limited Elsevier
Publisher_xml	– name: Elsevier Inc – name: Elsevier Limited – name: Elsevier
References	Liberzon, Taylor, Phan, Britton, Fig, Bueller, Koeppe, Zubieta (bib37) 2007; 61 Vehtari, Lampinen (bib62) 2002; 14 Gross-Isseroff, Dillon, Israeli, Biegon (bib20) 1990; 530 Ji, Neugebauer (bib25) 2009; 102 Lammertsma, Hume (bib33) 1996; 4 Watanabe, Fitting, Hussain, Kononenko, Iatsyshyna, Yoshitake, Kehr, Alkass, Druid, Wadensten, Andren, Nylander, Wedell, Krishtal, Hauser, Nyberg, Karpyak, Yakovleva, Bakalkin (bib65) 2015; 25 Koepp, Hammers, Lawrence, Asselin, Grasby, Bench (bib32) 2009; 44 Smith, Stohler, Nichols, Bueller, Koeppe, Zubieta (bib59) 2006; 26 Lindquist, Gelman (bib38) 2009; 4 Nasreddine, Saver (bib46) 1997; 48 Karjalainen, Tuisku, Santavirta, Kantonen, Bucci, Tuominen, Hirvonen, Hietala, Rinne, Nummenmaa (bib27) 2020; 14 Machin, Dunbar (bib42) 2011; 148 Corder, Castro, Bruchas, Scherrer (bib9) 2018; 41 Zubieta, Dannals, Frost (bib71) 1999; 156 Peciña, Karp, Mathew, Todtenkopf, Ehrich, Zubieta (bib48) 2019; 24 Maidment, Brumbaugh, Rudolph, Erdelyi, Evans (bib43) 1989; 33 Kennedy, Koeppe, Young, Zubieta (bib31) 2006; 63 Stuber, Sparta, Stamatakis, van Leeuwen, Hardjoprajitno, Cho, Tye, Kempadoo, Zhang, Deisseroth, Bonci (bib60) 2011; 475 van Hecke, Torrance, Smith (bib61) 2013; 111 Petrillo, Tavani, Verotta, Robson, Kosterlitz (bib49) 1987; 31 Barden, Dupont, Labrie, Mérand, Rouleau, Vaudry, Boissier (bib2) 1981; 208 Saanijoki, Tuominen, Tuulari, Nummenmaa, Arponen, Kalliokoski, Hirvonen (bib56) 2018; 43 Benjamin, Berger, Johannesson, Nosek, Wagenmakers, Berk, Bollen, Brembs, Brown, Camerer, Cesarini, Chambers, Clyde, Cook, De Boeck, Dienes, Dreber, Easwaran, Efferson, Fehr, Fidler, Field, Forster, George, Gonzalez, Goodman, Green, Green, Greenwald, Hadfield, Hedges, Held, Hua Ho, Hoijtink, Hruschka, Imai, Imbens, Ioannidis, Jeon, Jones, Kirchler, Laibson, List, Little, Lupia, Machery, Maxwell, McCarthy, Moore, Morgan, Munafó, Nakagawa, Nyhan, Parker, Pericchi, Perugini, Rouder, Rousseau, Savalei, Schönbrodt, Sellke, Sinclair, Tingley, Van Zandt, Vazire, Watts, Winship, Wolpert, Xie, Young, Zinman, Johnson (bib3) 2018; 2 Jones, Watabe, Cunningham, Jones (bib26) 2004; 8 Gabry, Simpson, Vehtari, Betancourt, Gelman (bib15) 2019; 182 Zalsman, Molcho, Huang, Dwork, Li, Mann (bib70) 2005; 112 Mintun, Raichle, Kilbourn, Wooten, Welch (bib45) 1984; 15 Walters, Cleck, Kuo, Blendy (bib63) 2005; 46 Lutz, Kieffer (bib41) 2013; 36 Quiñones-Jenab, Jenab, Ogawa, Inturrisi, Pfaff (bib53) 1997; 47 Scott, Domino, Heitzeg, Koeppe, Ni, Guthrie, Zubieta (bib57) 2007; 32 Good, Johnsrude, Ashburner, Henson, Friston, Frackowiak (bib19) 2001; 14 Simmons, Nelson, Simonsohn (bib58) 2011; 22 Cremers, Wager, Yarkoni (bib10) 2017; 12 Prentice, Jebb (bib51) 2001; 2 Button, Ioannidis, Mokrysz, Nosek, Flint, Robinson, Munafò (bib5) 2013; 14 Gelman, Carlin, Stern, Dunson, Vehtari, Rubin (bib16) 2013 Weerts, Wand, Kuwabara, Xu, Frost, Wong, McCaul (bib68) 2014; 19 Quelch, Katsouri, Nutt, Parker, Tyacke (bib52) 2014; 34 Gelman, Hill, Yajima (bib18) 2012; 5 Poldrack, Baker, Durnez, Gorgolewski, Matthews, Munafò, Nichols, Poline, Vul, Yarkoni (bib50) 2017; 18 Weerts, McCaul, Kuwabara, Yang, Xu, Dannals, Frost, Wong, Wand (bib66) 2013; 16 Loken, Gelman (bib40) 2017; 355 Herrero, Barcia, Navarro (bib23) 2002; 18 Gabilondo, Meana, Garcia-Sevilla (bib14) 1995; 682 Woolf, Pfleger (bib69) 2003; 81 Zubieta, Smith, Bueller, Xu, Kilbourn, Jewett, Meyer, Koeppe, Stohler (bib72) 2001; 293 Davenport, Houdi, Van Loon (bib11) 1990; 113 Karlsson, Tuominen, Tuulari, Hirvonen, Parkkola, Helin, Salminen, Nuutila, Nummenmaa (bib28) 2015; 35 Gelman, Hill (bib17) 2006 Bürkner (bib6) 2017; 80 Harris, Clauw, Scott, McLean, Gracely, Zubieta (bib21) 2007; 27 Innis, Cunningham, Delforge, Fujita, Gjedde, Gunn, Holden, Houle, Huang, Ichise, Iida, Ito, Kimura, Koeppe, Knudsen, Knuuti, Lammertsma, Laruelle, Logan, Maguire, Mintun, Morris, Parsey, Price, Slifstein, Sossi, Suhara, Votaw, Wong, Carson (bib24) 2007; 27 Katz, Mazer (bib30) 2009; 25 Lautenbacher, Peters, Heesen, Scheel, Kunz (bib35) 2017; 75 Lockhart, DeCarli (bib39) 2014; 24 Ashok, Myers, Reis Marques, Rabiner, Howes (bib1) 2019; 10 Lanteaume, Khalfa, Regis, Marquis, Chauvel, Bartolomei (bib34) 2007; 17 Cooke, Nanjappa, Ko, Prins, Hess (bib8) 2017; 97 Majuri, Joutsa, Johansson, Voon, Alakurtti, Parkkola, Lahti, Alho, Hirvonen, Arponen, Forsback, Kaasinen (bib44) 2017; 42 Nummenmaa, Tuominen (bib47) 2018; 175 Rodriguez, Noristani, Verkhratsky (bib55) 2012; 99 Frost, Douglass, Mayberg, Dannals, Links, Wilson (bib13) 1989; 9 Burghardt, Rothberg, Dykhuis, Burant, Zubieta (bib4) 2015; 100 Lesscher, Bailey, Burbach, Van Ree, Kitchen, Gerrits (bib36) 2003; 17 Contet, Kieffer, Befort (bib7) 2004; 14 Karrer, Josef, Mata, Morris, Samanez-Larkin (bib29) 2017; 57 Wand, Weerts, Kuwabara, Frost, Xu, McCaul (bib64) 2011; 36 Henriksen, Willoch (bib22) 2008; 131 Weerts, Wand, Kuwabara, Munro, Dannals, Hilton, Frost, McCaul (bib67) 2011; 35 Ray, Ruparel, Newberg, Wileyto, Loughead, Divgi, Blendy, Logan, Zubieta, Lerman (bib54) 2011; 108 Eklund, Nichols, Knutsson (bib12) 2016; 113 van Hecke (10.1016/j.neuroimage.2020.116922_bib61) 2013; 111 Saanijoki (10.1016/j.neuroimage.2020.116922_bib56) 2018; 43 Majuri (10.1016/j.neuroimage.2020.116922_bib44) 2017; 42 Quelch (10.1016/j.neuroimage.2020.116922_bib52) 2014; 34 Cremers (10.1016/j.neuroimage.2020.116922_bib10) 2017; 12 Weerts (10.1016/j.neuroimage.2020.116922_bib66) 2013; 16 Jones (10.1016/j.neuroimage.2020.116922_bib26) 2004; 8 Corder (10.1016/j.neuroimage.2020.116922_bib9) 2018; 41 Lautenbacher (10.1016/j.neuroimage.2020.116922_bib35) 2017; 75 Katz (10.1016/j.neuroimage.2020.116922_bib30) 2009; 25 Lanteaume (10.1016/j.neuroimage.2020.116922_bib34) 2007; 17 Simmons (10.1016/j.neuroimage.2020.116922_bib58) 2011; 22 Gelman (10.1016/j.neuroimage.2020.116922_bib17) 2006 Gelman (10.1016/j.neuroimage.2020.116922_bib18) 2012; 5 Ray (10.1016/j.neuroimage.2020.116922_bib54) 2011; 108 Cooke (10.1016/j.neuroimage.2020.116922_bib8) 2017; 97 Machin (10.1016/j.neuroimage.2020.116922_bib42) 2011; 148 Gabilondo (10.1016/j.neuroimage.2020.116922_bib14) 1995; 682 Henriksen (10.1016/j.neuroimage.2020.116922_bib22) 2008; 131 Benjamin (10.1016/j.neuroimage.2020.116922_bib3) 2018; 2 Karrer (10.1016/j.neuroimage.2020.116922_bib29) 2017; 57 Davenport (10.1016/j.neuroimage.2020.116922_bib11) 1990; 113 Lesscher (10.1016/j.neuroimage.2020.116922_bib36) 2003; 17 Contet (10.1016/j.neuroimage.2020.116922_bib7) 2004; 14 Woolf (10.1016/j.neuroimage.2020.116922_bib69) 2003; 81 Good (10.1016/j.neuroimage.2020.116922_bib19) 2001; 14 Petrillo (10.1016/j.neuroimage.2020.116922_bib49) 1987; 31 Ashok (10.1016/j.neuroimage.2020.116922_bib1) 2019; 10 Barden (10.1016/j.neuroimage.2020.116922_bib2) 1981; 208 Weerts (10.1016/j.neuroimage.2020.116922_bib68) 2014; 19 Nummenmaa (10.1016/j.neuroimage.2020.116922_bib47) 2018; 175 Zubieta (10.1016/j.neuroimage.2020.116922_bib72) 2001; 293 Lindquist (10.1016/j.neuroimage.2020.116922_bib38) 2009; 4 Kennedy (10.1016/j.neuroimage.2020.116922_bib31) 2006; 63 Mintun (10.1016/j.neuroimage.2020.116922_bib45) 1984; 15 Herrero (10.1016/j.neuroimage.2020.116922_bib23) 2002; 18 Nasreddine (10.1016/j.neuroimage.2020.116922_bib46) 1997; 48 Ji (10.1016/j.neuroimage.2020.116922_bib25) 2009; 102 Wand (10.1016/j.neuroimage.2020.116922_bib64) 2011; 36 Liberzon (10.1016/j.neuroimage.2020.116922_bib37) 2007; 61 Zubieta (10.1016/j.neuroimage.2020.116922_bib71) 1999; 156 Prentice (10.1016/j.neuroimage.2020.116922_bib51) 2001; 2 Gabry (10.1016/j.neuroimage.2020.116922_bib15) 2019; 182 Gross-Isseroff (10.1016/j.neuroimage.2020.116922_bib20) 1990; 530 Bürkner (10.1016/j.neuroimage.2020.116922_bib6) 2017; 80 Frost (10.1016/j.neuroimage.2020.116922_bib13) 1989; 9 Karjalainen (10.1016/j.neuroimage.2020.116922_bib27) 2020; 14 Scott (10.1016/j.neuroimage.2020.116922_bib57) 2007; 32 Weerts (10.1016/j.neuroimage.2020.116922_bib67) 2011; 35 Harris (10.1016/j.neuroimage.2020.116922_bib21) 2007; 27 Lutz (10.1016/j.neuroimage.2020.116922_bib41) 2013; 36 Rodriguez (10.1016/j.neuroimage.2020.116922_bib55) 2012; 99 Button (10.1016/j.neuroimage.2020.116922_bib5) 2013; 14 Vehtari (10.1016/j.neuroimage.2020.116922_bib62) 2002; 14 Gelman (10.1016/j.neuroimage.2020.116922_bib16) 2013 Smith (10.1016/j.neuroimage.2020.116922_bib59) 2006; 26 Koepp (10.1016/j.neuroimage.2020.116922_bib32) 2009; 44 Lammertsma (10.1016/j.neuroimage.2020.116922_bib33) 1996; 4 Poldrack (10.1016/j.neuroimage.2020.116922_bib50) 2017; 18 Watanabe (10.1016/j.neuroimage.2020.116922_bib65) 2015; 25 Peciña (10.1016/j.neuroimage.2020.116922_bib48) 2019; 24 Karlsson (10.1016/j.neuroimage.2020.116922_bib28) 2015; 35 Quiñones-Jenab (10.1016/j.neuroimage.2020.116922_bib53) 1997; 47 Innis (10.1016/j.neuroimage.2020.116922_bib24) 2007; 27 Maidment (10.1016/j.neuroimage.2020.116922_bib43) 1989; 33 Burghardt (10.1016/j.neuroimage.2020.116922_bib4) 2015; 100 Eklund (10.1016/j.neuroimage.2020.116922_bib12) 2016; 113 Walters (10.1016/j.neuroimage.2020.116922_bib63) 2005; 46 Stuber (10.1016/j.neuroimage.2020.116922_bib60) 2011; 475 Zalsman (10.1016/j.neuroimage.2020.116922_bib70) 2005; 112 Lockhart (10.1016/j.neuroimage.2020.116922_bib39) 2014; 24 Loken (10.1016/j.neuroimage.2020.116922_bib40) 2017; 355
References_xml	– volume: 18 start-page: 386 year: 2002 end-page: 404 ident: bib23 article-title: Functional anatomy of thalamus and basal ganglia publication-title: Childs Nerv. Syst. – volume: 27 start-page: 10000 year: 2007 end-page: 10006 ident: bib21 article-title: Decreased central mu-opioid receptor availability in fibromyalgia publication-title: J. Neurosci. – volume: 99 start-page: 15 year: 2012 end-page: 41 ident: bib55 article-title: The serotonergic system in ageing and Alzheimer’s disease publication-title: Prog. Neurobiol. – volume: 19 start-page: 733 year: 2014 end-page: 742 ident: bib68 article-title: Association of smoking with mu-opioid receptor availability before and during naltrexone blockade in alcohol-dependent subjects publication-title: Addiction Biol. – volume: 35 start-page: 2162 year: 2011 end-page: 2173 ident: bib67 article-title: Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjects publication-title: Alcohol Clin. Exp. Res. – volume: 9 start-page: 398 year: 1989 end-page: 409 ident: bib13 article-title: Multicompartmental analysis of [11C]-carfentanil binding to opiate receptors in humans measured by positron emission tomography publication-title: J. Cerebr. Blood Flow Metabol. – volume: 80 start-page: 1 year: 2017 end-page: 28 ident: bib6 article-title: brms: an R package for Bayesian multilevel models using Stan publication-title: J. Stat. Software – volume: 14 year: 2020 ident: bib27 article-title: Magia: robust automated image processing and kinetic modeling toolbox for PET neuroinformatics publication-title: Front. Neuroinf. – volume: 16 start-page: 47 year: 2013 end-page: 53 ident: bib66 article-title: Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects publication-title: Int. J. Neuropsychopharmacol. – volume: 46 start-page: 933 year: 2005 end-page: 943 ident: bib63 article-title: Mu-opioid receptor and CREB activation are required for nicotine reward publication-title: Neuron – volume: 32 start-page: 450 year: 2007 end-page: 457 ident: bib57 article-title: Smoking modulation of mu-opioid and dopamine D2 receptor-mediated neurotransmission in humans publication-title: Neuropsychopharmacology – volume: 35 start-page: 3959 year: 2015 end-page: 3965 ident: bib28 article-title: Obesity is associated with decreased mu-opioid but unaltered dopamine D2 receptor availability in the brain publication-title: J. Neurosci. – volume: 175 start-page: 2737 year: 2018 end-page: 2749 ident: bib47 article-title: Opioid system and human emotions publication-title: Br. J. Pharmacol. – volume: 41 start-page: 453 year: 2018 end-page: 473 ident: bib9 article-title: Endogenous and exogenous opioids in pain publication-title: Annu. Rev. Neurosci. – volume: 25 start-page: 97 year: 2015 end-page: 108 ident: bib65 article-title: Asymmetry of the endogenous opioid system in the human anterior cingulate: a putative molecular basis for lateralization of emotions and pain publication-title: Cerebr. Cortex – volume: 34 start-page: 1604 year: 2014 end-page: 1612 ident: bib52 article-title: Imaging endogenous opioid peptide release with [11C]carfentanil and [3H]diprenorphine: influence of agonist-induced internalization publication-title: J. Cerebr. Blood Flow Metabol. – volume: 26 start-page: 5777 year: 2006 end-page: 5785 ident: bib59 article-title: Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women publication-title: J. Neurosci. – volume: 2 start-page: 6 year: 2018 end-page: 10 ident: bib3 article-title: Redefine statistical significance publication-title: Nat. Hum. Behav. – volume: 36 start-page: 1453 year: 2011 end-page: 1459 ident: bib64 article-title: Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjects publication-title: Psychoneuroendocrinology – volume: 57 start-page: 36 year: 2017 end-page: 46 ident: bib29 article-title: Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis publication-title: Neurobiol. Aging – volume: 36 start-page: 195 year: 2013 end-page: 206 ident: bib41 article-title: Opioid receptors: distinct roles in mood disorders publication-title: Trends Neurosci. – volume: 5 start-page: 189 year: 2012 end-page: 211 ident: bib18 article-title: Why we (usually) don’t have to worry about multiple comparisons publication-title: J. Res. Educ. Effect. – volume: 102 start-page: 2253 year: 2009 end-page: 2264 ident: bib25 article-title: Hemispheric lateralization of pain processing by amygdala neurons publication-title: J. Neurophysiol. – volume: 42 start-page: 1169 year: 2017 end-page: 1177 ident: bib44 article-title: Dopamine and opioid neurotransmission in behavioral addictions: a comparative PET study in pathological gambling and binge eating publication-title: Neuropsychopharmacology – year: 2006 ident: bib17 article-title: Data Analysis Using Regression and Multilevel/hierarchical Models – volume: 148 start-page: 985 year: 2011 end-page: 1025 ident: bib42 article-title: The brain opioid theory of social attachment: a review of the evidence publication-title: Behaviour – volume: 33 start-page: 549 year: 1989 end-page: 557 ident: bib43 article-title: Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo publication-title: Neuroscience – volume: 108 start-page: 9268 year: 2011 end-page: 9273 ident: bib54 article-title: Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 17 start-page: 1307 year: 2007 end-page: 1313 ident: bib34 article-title: Emotion induction after direct intracerebral stimulations of human amygdala publication-title: Cerebr. Cortex – volume: 682 start-page: 245 year: 1995 end-page: 250 ident: bib14 article-title: Increased density of mu-opioid receptors in the postmortem brain of suicide victims publication-title: Brain Res. – volume: 156 start-page: 842 year: 1999 end-page: 848 ident: bib71 article-title: Gender and age influences on human brain mu-opioid receptor binding measured by PET publication-title: Am. J. Psychiatr. – volume: 48 start-page: 1196 year: 1997 ident: bib46 article-title: Pain after thalarnic stroke publication-title: Neurology – volume: 112 start-page: 949 year: 2005 end-page: 954 ident: bib70 article-title: Postmortem μ-opioid receptor binding in suicide victims and controls publication-title: J. Neural. Transm. – volume: 22 start-page: 1359 year: 2011 end-page: 1366 ident: bib58 article-title: False-positive psychology: undisclosed flexibility in data collection and analysis allows presenting anything as significant publication-title: Psychol. Sci. – volume: 4 start-page: 153 year: 1996 end-page: 158 ident: bib33 article-title: Simplified reference tissue model for PET receptor studies publication-title: Neuroimage – volume: 81 start-page: 646 year: 2003 end-page: 656 ident: bib69 article-title: Burden of major musculoskeletal conditions publication-title: Bull. World Health Organ. – volume: 475 start-page: 377 year: 2011 end-page: 380 ident: bib60 article-title: Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking publication-title: Nature – volume: 111 start-page: 13 year: 2013 end-page: 18 ident: bib61 article-title: Chronic pain epidemiology and its clinical relevance publication-title: Br. J. Anaesth. – volume: 113 start-page: 7900 year: 2016 end-page: 7905 ident: bib12 article-title: Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 15 start-page: 217 year: 1984 end-page: 227 ident: bib45 article-title: A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography publication-title: Ann. Neurol. – volume: 17 start-page: 1006 year: 2003 end-page: 1012 ident: bib36 article-title: Receptor-selective changes in mu-, delta- and kappa-opioid receptors after chronic naltrexone treatment in mice publication-title: Eur. J. Neurosci. – volume: 293 start-page: 311 year: 2001 end-page: 315 ident: bib72 article-title: Regional mu opioid receptor regulation of sensory and affective dimensions of pain publication-title: Science – volume: 61 start-page: 1030 year: 2007 end-page: 1038 ident: bib37 article-title: Altered central micro-opioid receptor binding after psychological trauma publication-title: Biol. Psychiatr. – volume: 355 start-page: 584 year: 2017 ident: bib40 article-title: Measurement error and the replication crisis publication-title: Science – volume: 208 start-page: 209 year: 1981 end-page: 212 ident: bib2 article-title: Age-dependent changes in the β-endorphin content of discrete rat brain nuclei publication-title: Brain Res. – volume: 10 start-page: 4493 year: 2019 ident: bib1 article-title: Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging publication-title: Nat. Commun. – volume: 530 start-page: 312 year: 1990 end-page: 316 ident: bib20 article-title: Regionally selective increases in mu opioid receptor density in the brains of suicide victims publication-title: Brain Res. – volume: 131 start-page: 1171 year: 2008 end-page: 1196 ident: bib22 article-title: Imaging of opioid receptors in the central nervous system publication-title: Brain – volume: 25 start-page: 170 year: 2009 end-page: 175 ident: bib30 article-title: The impact of opioids on the endocrine system publication-title: Clin. J. Pain – volume: 44 start-page: 252 year: 2009 end-page: 256 ident: bib32 article-title: Evidence for endogenous opioid release in the amygdala during positive emotion publication-title: Neuroimage – volume: 182 start-page: 389 year: 2019 end-page: 402 ident: bib15 article-title: Visualization in bayesian workflow publication-title: J. Roy. Stat. Soc. – year: 2013 ident: bib16 article-title: Bayesian Data Analysis – volume: 24 start-page: 576 year: 2019 end-page: 587 ident: bib48 article-title: Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches publication-title: Mol. Psychiatr. – volume: 47 start-page: 134 year: 1997 end-page: 138 ident: bib53 article-title: Estrogen regulation of μ-opioid receptor mRNA in the forebrain of female rats publication-title: Mol. Brain Res. – volume: 43 start-page: 246 year: 2018 end-page: 254 ident: bib56 article-title: Opioid release after high-intensity interval training in healthy human subjects publication-title: Neuropsychopharmacology – volume: 14 start-page: 2439 year: 2002 end-page: 2468 ident: bib62 article-title: Bayesian model assessment and comparison using cross-validation predictive densities publication-title: Neural Comput. – volume: 63 start-page: 1199 year: 2006 end-page: 1208 ident: bib31 article-title: Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women publication-title: Arch. Gen. Psychiatr. – volume: 2 start-page: 141 year: 2001 end-page: 147 ident: bib51 article-title: Beyond body mass index publication-title: Obes. Rev. – volume: 100 start-page: 3193 year: 2015 end-page: 3201 ident: bib4 article-title: Endogenous opioid mechanisms are implicated in obesity and weight loss in humans publication-title: J. Clin. Endocrinol. Metab. – volume: 97 start-page: 995 year: 2017 end-page: 1043 ident: bib8 article-title: Estrogens in male physiology publication-title: Physiol. Rev. – volume: 24 start-page: 271 year: 2014 end-page: 289 ident: bib39 article-title: Structural imaging measures of brain aging publication-title: Neuropsychol. Rev. – volume: 14 start-page: 370 year: 2004 end-page: 378 ident: bib7 article-title: Mu opioid receptor: a gateway to drug addiction publication-title: Curr. Opin. Neurobiol. – volume: 14 start-page: 365 year: 2013 end-page: 376 ident: bib5 article-title: Power failure: why small sample size undermines the reliability of neuroscience publication-title: Nat. Rev. Neurosci. – volume: 27 start-page: 1533 year: 2007 end-page: 1539 ident: bib24 article-title: Consensus nomenclature for in vivo imaging of reversibly binding radioligands publication-title: J. Cerebr. Blood Flow Metabol. – volume: 31 start-page: 53 year: 1987 end-page: 58 ident: bib49 article-title: Differential postnatal development of μ-, δ-and χ-opioid binding sites in rat brain publication-title: Dev. Brain Res. – volume: 14 start-page: 21 year: 2001 end-page: 36 ident: bib19 article-title: A voxel-based morphometric study of ageing in 465 normal adult human brains publication-title: Neuroimage – volume: 12 year: 2017 ident: bib10 article-title: The relation between statistical power and inference in fMRI publication-title: PloS One – volume: 113 start-page: 40 year: 1990 end-page: 46 ident: bib11 article-title: Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain publication-title: Neurosci. Lett. – volume: 8 start-page: 479 year: 2004 end-page: 485 ident: bib26 article-title: Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET publication-title: Eur. J. Pain – volume: 4 start-page: 310 year: 2009 end-page: 313 ident: bib38 article-title: Correlations and Multiple Comparisons in Functional Imaging: a Statistical Perspective (Commentary on Vul et al., 2009) publication-title: Perspect. Psychol. Sci. – volume: 75 start-page: 104 year: 2017 end-page: 113 ident: bib35 article-title: Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds publication-title: Neurosci. Biobehav. Rev. – volume: 18 start-page: 115 year: 2017 end-page: 126 ident: bib50 article-title: Scanning the horizon: towards transparent and reproducible neuroimaging research publication-title: Nat. Rev. Neurosci. – volume: 48 start-page: 1196 year: 1997 ident: 10.1016/j.neuroimage.2020.116922_bib46 article-title: Pain after thalarnic stroke publication-title: Neurology doi: 10.1212/WNL.48.5.1196 – volume: 148 start-page: 985 year: 2011 ident: 10.1016/j.neuroimage.2020.116922_bib42 article-title: The brain opioid theory of social attachment: a review of the evidence publication-title: Behaviour doi: 10.1163/000579511X596624 – volume: 15 start-page: 217 year: 1984 ident: 10.1016/j.neuroimage.2020.116922_bib45 article-title: A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography publication-title: Ann. Neurol. doi: 10.1002/ana.410150302 – volume: 14 start-page: 365 year: 2013 ident: 10.1016/j.neuroimage.2020.116922_bib5 article-title: Power failure: why small sample size undermines the reliability of neuroscience publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3475 – volume: 25 start-page: 97 year: 2015 ident: 10.1016/j.neuroimage.2020.116922_bib65 article-title: Asymmetry of the endogenous opioid system in the human anterior cingulate: a putative molecular basis for lateralization of emotions and pain publication-title: Cerebr. Cortex doi: 10.1093/cercor/bht204 – volume: 113 start-page: 7900 year: 2016 ident: 10.1016/j.neuroimage.2020.116922_bib12 article-title: Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1602413113 – volume: 111 start-page: 13 year: 2013 ident: 10.1016/j.neuroimage.2020.116922_bib61 article-title: Chronic pain epidemiology and its clinical relevance publication-title: Br. J. Anaesth. doi: 10.1093/bja/aet123 – volume: 18 start-page: 386 year: 2002 ident: 10.1016/j.neuroimage.2020.116922_bib23 article-title: Functional anatomy of thalamus and basal ganglia publication-title: Childs Nerv. Syst. doi: 10.1007/s00381-002-0604-1 – volume: 208 start-page: 209 year: 1981 ident: 10.1016/j.neuroimage.2020.116922_bib2 article-title: Age-dependent changes in the β-endorphin content of discrete rat brain nuclei publication-title: Brain Res. doi: 10.1016/0006-8993(81)90634-X – volume: 14 year: 2020 ident: 10.1016/j.neuroimage.2020.116922_bib27 article-title: Magia: robust automated image processing and kinetic modeling toolbox for PET neuroinformatics publication-title: Front. Neuroinf. doi: 10.3389/fninf.2020.00003 – volume: 63 start-page: 1199 year: 2006 ident: 10.1016/j.neuroimage.2020.116922_bib31 article-title: Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women publication-title: Arch. Gen. Psychiatr. doi: 10.1001/archpsyc.63.11.1199 – year: 2006 ident: 10.1016/j.neuroimage.2020.116922_bib17 – volume: 61 start-page: 1030 year: 2007 ident: 10.1016/j.neuroimage.2020.116922_bib37 article-title: Altered central micro-opioid receptor binding after psychological trauma publication-title: Biol. Psychiatr. doi: 10.1016/j.biopsych.2006.06.021 – volume: 19 start-page: 733 year: 2014 ident: 10.1016/j.neuroimage.2020.116922_bib68 article-title: Association of smoking with mu-opioid receptor availability before and during naltrexone blockade in alcohol-dependent subjects publication-title: Addiction Biol. doi: 10.1111/adb.12022 – volume: 99 start-page: 15 year: 2012 ident: 10.1016/j.neuroimage.2020.116922_bib55 article-title: The serotonergic system in ageing and Alzheimer’s disease publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2012.06.010 – volume: 75 start-page: 104 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib35 article-title: Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2017.01.039 – volume: 57 start-page: 36 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib29 article-title: Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2017.05.006 – volume: 24 start-page: 576 year: 2019 ident: 10.1016/j.neuroimage.2020.116922_bib48 article-title: Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches publication-title: Mol. Psychiatr. doi: 10.1038/s41380-018-0117-2 – volume: 102 start-page: 2253 year: 2009 ident: 10.1016/j.neuroimage.2020.116922_bib25 article-title: Hemispheric lateralization of pain processing by amygdala neurons publication-title: J. Neurophysiol. doi: 10.1152/jn.00166.2009 – volume: 2 start-page: 6 year: 2018 ident: 10.1016/j.neuroimage.2020.116922_bib3 article-title: Redefine statistical significance publication-title: Nat. Hum. Behav. doi: 10.1038/s41562-017-0189-z – volume: 44 start-page: 252 year: 2009 ident: 10.1016/j.neuroimage.2020.116922_bib32 article-title: Evidence for endogenous opioid release in the amygdala during positive emotion publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.08.032 – volume: 41 start-page: 453 year: 2018 ident: 10.1016/j.neuroimage.2020.116922_bib9 article-title: Endogenous and exogenous opioids in pain publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev-neuro-080317-061522 – volume: 27 start-page: 10000 year: 2007 ident: 10.1016/j.neuroimage.2020.116922_bib21 article-title: Decreased central mu-opioid receptor availability in fibromyalgia publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2849-07.2007 – volume: 17 start-page: 1307 year: 2007 ident: 10.1016/j.neuroimage.2020.116922_bib34 article-title: Emotion induction after direct intracerebral stimulations of human amygdala publication-title: Cerebr. Cortex doi: 10.1093/cercor/bhl041 – volume: 33 start-page: 549 year: 1989 ident: 10.1016/j.neuroimage.2020.116922_bib43 article-title: Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo publication-title: Neuroscience doi: 10.1016/0306-4522(89)90407-7 – volume: 8 start-page: 479 year: 2004 ident: 10.1016/j.neuroimage.2020.116922_bib26 article-title: Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET publication-title: Eur. J. Pain doi: 10.1016/j.ejpain.2003.11.017 – volume: 47 start-page: 134 year: 1997 ident: 10.1016/j.neuroimage.2020.116922_bib53 article-title: Estrogen regulation of μ-opioid receptor mRNA in the forebrain of female rats publication-title: Mol. Brain Res. doi: 10.1016/S0169-328X(97)00041-7 – volume: 36 start-page: 195 year: 2013 ident: 10.1016/j.neuroimage.2020.116922_bib41 article-title: Opioid receptors: distinct roles in mood disorders publication-title: Trends Neurosci. doi: 10.1016/j.tins.2012.11.002 – volume: 36 start-page: 1453 year: 2011 ident: 10.1016/j.neuroimage.2020.116922_bib64 article-title: Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjects publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2011.03.019 – volume: 14 start-page: 2439 year: 2002 ident: 10.1016/j.neuroimage.2020.116922_bib62 article-title: Bayesian model assessment and comparison using cross-validation predictive densities publication-title: Neural Comput. doi: 10.1162/08997660260293292 – volume: 27 start-page: 1533 year: 2007 ident: 10.1016/j.neuroimage.2020.116922_bib24 article-title: Consensus nomenclature for in vivo imaging of reversibly binding radioligands publication-title: J. Cerebr. Blood Flow Metabol. doi: 10.1038/sj.jcbfm.9600493 – volume: 22 start-page: 1359 year: 2011 ident: 10.1016/j.neuroimage.2020.116922_bib58 article-title: False-positive psychology: undisclosed flexibility in data collection and analysis allows presenting anything as significant publication-title: Psychol. Sci. doi: 10.1177/0956797611417632 – volume: 355 start-page: 584 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib40 article-title: Measurement error and the replication crisis publication-title: Science doi: 10.1126/science.aal3618 – volume: 9 start-page: 398 year: 1989 ident: 10.1016/j.neuroimage.2020.116922_bib13 article-title: Multicompartmental analysis of [11C]-carfentanil binding to opiate receptors in humans measured by positron emission tomography publication-title: J. Cerebr. Blood Flow Metabol. doi: 10.1038/jcbfm.1989.59 – volume: 175 start-page: 2737 year: 2018 ident: 10.1016/j.neuroimage.2020.116922_bib47 article-title: Opioid system and human emotions publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13812 – volume: 32 start-page: 450 year: 2007 ident: 10.1016/j.neuroimage.2020.116922_bib57 article-title: Smoking modulation of mu-opioid and dopamine D2 receptor-mediated neurotransmission in humans publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301238 – volume: 35 start-page: 3959 year: 2015 ident: 10.1016/j.neuroimage.2020.116922_bib28 article-title: Obesity is associated with decreased mu-opioid but unaltered dopamine D2 receptor availability in the brain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4744-14.2015 – volume: 5 start-page: 189 year: 2012 ident: 10.1016/j.neuroimage.2020.116922_bib18 article-title: Why we (usually) don’t have to worry about multiple comparisons publication-title: J. Res. Educ. Effect. – volume: 25 start-page: 170 year: 2009 ident: 10.1016/j.neuroimage.2020.116922_bib30 article-title: The impact of opioids on the endocrine system publication-title: Clin. J. Pain doi: 10.1097/AJP.0b013e3181850df6 – volume: 156 start-page: 842 year: 1999 ident: 10.1016/j.neuroimage.2020.116922_bib71 article-title: Gender and age influences on human brain mu-opioid receptor binding measured by PET publication-title: Am. J. Psychiatr. doi: 10.1176/ajp.156.6.842 – volume: 10 start-page: 4493 year: 2019 ident: 10.1016/j.neuroimage.2020.116922_bib1 article-title: Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging publication-title: Nat. Commun. doi: 10.1038/s41467-019-12366-4 – volume: 14 start-page: 370 year: 2004 ident: 10.1016/j.neuroimage.2020.116922_bib7 article-title: Mu opioid receptor: a gateway to drug addiction publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2004.05.005 – volume: 97 start-page: 995 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib8 article-title: Estrogens in male physiology publication-title: Physiol. Rev. doi: 10.1152/physrev.00018.2016 – volume: 182 start-page: 389 year: 2019 ident: 10.1016/j.neuroimage.2020.116922_bib15 article-title: Visualization in bayesian workflow publication-title: J. Roy. Stat. Soc. doi: 10.1111/rssa.12378 – volume: 80 start-page: 1 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib6 article-title: brms: an R package for Bayesian multilevel models using Stan publication-title: J. Stat. Software – volume: 113 start-page: 40 year: 1990 ident: 10.1016/j.neuroimage.2020.116922_bib11 article-title: Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(90)90491-Q – volume: 4 start-page: 310 year: 2009 ident: 10.1016/j.neuroimage.2020.116922_bib38 article-title: Correlations and Multiple Comparisons in Functional Imaging: a Statistical Perspective (Commentary on Vul et al., 2009) publication-title: Perspect. Psychol. Sci. doi: 10.1111/j.1745-6924.2009.01130.x – volume: 2 start-page: 141 year: 2001 ident: 10.1016/j.neuroimage.2020.116922_bib51 article-title: Beyond body mass index publication-title: Obes. Rev. doi: 10.1046/j.1467-789x.2001.00031.x – volume: 46 start-page: 933 year: 2005 ident: 10.1016/j.neuroimage.2020.116922_bib63 article-title: Mu-opioid receptor and CREB activation are required for nicotine reward publication-title: Neuron doi: 10.1016/j.neuron.2005.05.005 – volume: 81 start-page: 646 year: 2003 ident: 10.1016/j.neuroimage.2020.116922_bib69 article-title: Burden of major musculoskeletal conditions publication-title: Bull. World Health Organ. – volume: 43 start-page: 246 year: 2018 ident: 10.1016/j.neuroimage.2020.116922_bib56 article-title: Opioid release after high-intensity interval training in healthy human subjects publication-title: Neuropsychopharmacology doi: 10.1038/npp.2017.148 – volume: 108 start-page: 9268 year: 2011 ident: 10.1016/j.neuroimage.2020.116922_bib54 article-title: Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1018699108 – volume: 26 start-page: 5777 year: 2006 ident: 10.1016/j.neuroimage.2020.116922_bib59 article-title: Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5223-05.2006 – volume: 18 start-page: 115 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib50 article-title: Scanning the horizon: towards transparent and reproducible neuroimaging research publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn.2016.167 – volume: 17 start-page: 1006 year: 2003 ident: 10.1016/j.neuroimage.2020.116922_bib36 article-title: Receptor-selective changes in mu-, delta- and kappa-opioid receptors after chronic naltrexone treatment in mice publication-title: Eur. J. Neurosci. doi: 10.1046/j.1460-9568.2003.02502.x – volume: 12 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib10 article-title: The relation between statistical power and inference in fMRI publication-title: PloS One doi: 10.1371/journal.pone.0184923 – volume: 31 start-page: 53 year: 1987 ident: 10.1016/j.neuroimage.2020.116922_bib49 article-title: Differential postnatal development of μ-, δ-and χ-opioid binding sites in rat brain publication-title: Dev. Brain Res. doi: 10.1016/0165-3806(87)90082-4 – year: 2013 ident: 10.1016/j.neuroimage.2020.116922_bib16 – volume: 4 start-page: 153 year: 1996 ident: 10.1016/j.neuroimage.2020.116922_bib33 article-title: Simplified reference tissue model for PET receptor studies publication-title: Neuroimage doi: 10.1006/nimg.1996.0066 – volume: 682 start-page: 245 year: 1995 ident: 10.1016/j.neuroimage.2020.116922_bib14 article-title: Increased density of mu-opioid receptors in the postmortem brain of suicide victims publication-title: Brain Res. doi: 10.1016/0006-8993(95)00333-L – volume: 16 start-page: 47 year: 2013 ident: 10.1016/j.neuroimage.2020.116922_bib66 article-title: Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S146114571200017X – volume: 100 start-page: 3193 year: 2015 ident: 10.1016/j.neuroimage.2020.116922_bib4 article-title: Endogenous opioid mechanisms are implicated in obesity and weight loss in humans publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2015-1783 – volume: 14 start-page: 21 year: 2001 ident: 10.1016/j.neuroimage.2020.116922_bib19 article-title: A voxel-based morphometric study of ageing in 465 normal adult human brains publication-title: Neuroimage doi: 10.1006/nimg.2001.0786 – volume: 131 start-page: 1171 year: 2008 ident: 10.1016/j.neuroimage.2020.116922_bib22 article-title: Imaging of opioid receptors in the central nervous system publication-title: Brain doi: 10.1093/brain/awm255 – volume: 34 start-page: 1604 year: 2014 ident: 10.1016/j.neuroimage.2020.116922_bib52 article-title: Imaging endogenous opioid peptide release with [11C]carfentanil and [3H]diprenorphine: influence of agonist-induced internalization publication-title: J. Cerebr. Blood Flow Metabol. doi: 10.1038/jcbfm.2014.117 – volume: 530 start-page: 312 year: 1990 ident: 10.1016/j.neuroimage.2020.116922_bib20 article-title: Regionally selective increases in mu opioid receptor density in the brains of suicide victims publication-title: Brain Res. doi: 10.1016/0006-8993(90)91301-V – volume: 42 start-page: 1169 year: 2017 ident: 10.1016/j.neuroimage.2020.116922_bib44 article-title: Dopamine and opioid neurotransmission in behavioral addictions: a comparative PET study in pathological gambling and binge eating publication-title: Neuropsychopharmacology doi: 10.1038/npp.2016.265 – volume: 475 start-page: 377 year: 2011 ident: 10.1016/j.neuroimage.2020.116922_bib60 article-title: Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking publication-title: Nature doi: 10.1038/nature10194 – volume: 24 start-page: 271 year: 2014 ident: 10.1016/j.neuroimage.2020.116922_bib39 article-title: Structural imaging measures of brain aging publication-title: Neuropsychol. Rev. doi: 10.1007/s11065-014-9268-3 – volume: 35 start-page: 2162 year: 2011 ident: 10.1016/j.neuroimage.2020.116922_bib67 article-title: Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjects publication-title: Alcohol Clin. Exp. Res. doi: 10.1111/j.1530-0277.2011.01565.x – volume: 112 start-page: 949 year: 2005 ident: 10.1016/j.neuroimage.2020.116922_bib70 article-title: Postmortem μ-opioid receptor binding in suicide victims and controls publication-title: J. Neural. Transm. doi: 10.1007/s00702-004-0239-3 – volume: 293 start-page: 311 year: 2001 ident: 10.1016/j.neuroimage.2020.116922_bib72 article-title: Regional mu opioid receptor regulation of sensory and affective dimensions of pain publication-title: Science doi: 10.1126/science.1060952
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Snippet	Alterations in the brain’s μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies... Alterations in the brain's μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies...
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SubjectTerms	[11C]carfentanil Adult Age Ageing Aging - physiology Amygdala Analgesics, Opioid Binding sites Body Mass Index Brain Chemistry - physiology Brain lateralization Brain research Chronic pain Endogenous opioids Epidemiology Female Fentanyl - analogs & derivatives Functional Laterality - physiology Hemispheric laterality Humans Individuality Male Mental disorders Middle Aged Narcotics Nucleus accumbens Opioid receptors Pain Positron emission tomography Radiopharmaceuticals Receptors, Opioid, mu - metabolism Researchers Scanners Sex Characteristics Smoking Specialization Studies Thalamus Young Adult μ-Opioid receptors
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Title	Interindividual variability and lateralization of μ-opioid receptors in the human brain
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