Monarubins A–C from the Marine Shellfish-Associated Fungus Monascus ruber BB5

• Published in: Marine drugs Vol. 18; no. 2; p. 100
• Main Authors: Ran, Yan-Qin, Lan, Wen-Jian, Qiu, Yi, Guo, Qi, Feng, Gong-Kan, Deng, Rong, Zhu, Xiao-Feng, Li, Hou-Jin, Dong, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.02.2020; MDPI
• Subjects: Cancer; Cell lines; Cytotoxicity; Fungi; Hepatocellular carcinoma; hepatoma; humans; Hydrocarbons; isocoumarins; Liver cancer; marine fungus; Marine molluscs; marine shellfish; Metabolites; Microorganisms; monarubin; Monascus ruber; Nasopharyngeal carcinoma; neoplasm cells; Neoplasms; NMR; Nuclear magnetic resonance; Polyketides; Shellfish; Throat cancer; Tumor cell lines; China; monarubin; marine shellfish; Monascus ruber; marine fungus; cytotoxicity

Three new compounds, monarubins A–C (1, 6 and 13), together with ten known compounds, including four alkaloids (2–5), two isocoumarins (7 and 8) and four polyketides (9–12), were isolated from marine shellfish-associated fungus Monascus ruber BB5. The structures were determined on the basis of the 1...