Parent-Metabolite Pharmacokinetic Modeling of Formononetin and Its Active Metabolites in Rats after Oral Administration of Formononetin Formulations

• Published in: Pharmaceutics Vol. 15; no. 1; p. 45
• Main Authors: Kim, Ju Hee, Kang, Dong Wook, Cho, Seok-Jin, Cho, Hea-Young
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.12.2022; MDPI
• Subjects: Acids; active metabolites; Bioavailability; daidzein; dihydrodaidzein; equol; Experiments; formononetin; Ions; Laboratory animals; Metabolites; Methods; Oral administration; Pharmacokinetics; Plasma; Proteins; UPLC-MS/MS; United States > US; daidzein; equol; active metabolites; formononetin; pharmacokinetics; UPLC-MS/MS; plasma protein binding; parent-metabolite pharamcokientic modeling; dihydrodaidzein

Formononetin is a major isoflavone contained in propolis and is reported to exhibit various pharmacological effects. However, the use of formononetin in pharmaceutical industry is limited due to its low bioavailability and solubility. There had been several efforts on formononetin formulation develo...