The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction

• Published in: The FASEB journal Vol. 33; no. 6; p. 7647
• Main Authors: De Palma, Ryan M, Parnham, Stuart R, Li, Yitong, Oaks, Joshua J, Peterson, Yuri K, Szulc, Zdzislaw M, Roth, Braden M, Xing, Yongna, Ogretmen, Besim
• Format: Journal Article
• Language: English
• Published: United States 01.06.2019
• Subjects: ceramide; lipid-protein binding; sphingolipid; fingolimod

The su(var)3-9, enhancer of zeste, trithorax (SET)/inhibitor 2 of protein phosphatase 2A (PP2A) oncoprotein binds and inhibits PP2A, composed of various isoforms of scaffolding, regulatory, and catalytic subunits. Targeting SET with a sphingolipid analog drug fingolimod (FTY720) or ceramide leads to...