Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites

• Published in: Journal of the American Heart Association Vol. 5; no. 10
• Main Authors: Chirinos, Julio A., Akers, Scott R., Trieu, Lien, Ischiropoulos, Harry, Doulias, Paschalis‐Thomas, Tariq, Ali, Vasim, Izzah, Koppula, Maheswara R., Syed, Amer Ahmed, Soto‐Calderon, Haideliza, Townsend, Raymond R., Cappola, Thomas P., Margulies, Kenneth B., Zamani, Payman
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.10.2016; Wiley
• Subjects: Aged; Case-Control Studies; diastolic heart failure; Female; Fibrosis; Heart - diagnostic imaging; heart failure; Heart Failure - blood; Heart Failure - physiopathology; Humans; Hypertrophy, Left Ventricular - blood; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - physiopathology; hypertrophy/remodeling; Magnetic Resonance Imaging; Male; Middle Aged; myocardial fibrosis; myocardial structure; Myocardium - pathology; Nitric Oxide - blood; Nitric Oxide - metabolism; Organ Size; Original Research; Prospective Studies; Stroke Volume; United States; United States Department of Veterans Affairs; Ventricular Remodeling; heart failure; diastolic heart failure; hypertrophy/remodeling; myocardial structure; myocardial fibrosis

Background Stable plasma nitric oxide (NO) metabolites (NOM), composed predominantly of nitrate and nitrite, are attractive biomarkers of NO bioavailability. NOM levels integrate the influence of NO‐synthase‐derived NO production/metabolism, dietary intake of inorganic nitrate/nitrite, and clearance...