How Small Heterocycles Make a Reaction Network of Amino Acids and Nucleotides Efficient in Water

• Published in: Angewandte Chemie International Edition Vol. 58; no. 37; pp. 13087 - 13092
• Main Authors: Tremmel, Peter, Griesser, Helmut, Steiner, Ulrich E., Richert, Clemens
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 09.09.2019; John Wiley and Sons Inc
• Edition: International ed. in English
• Subjects: Adenosine Monophosphate - chemistry; Adenosine Triphosphate - chemistry; Amino acids; Amino Acids - chemistry; AMP; Aqueous solutions; Carbodiimide; Carbodiimides - chemistry; Catalysis; Chemical bonds; Cyanamide - chemistry; Enzymes; Glycine; Heterocyclic Compounds - chemistry; Intermediates; Kinetics; Nucleotides; Nucleotides - chemistry; organocatalysis; Peptides; prebiotic chemistry; Pyrophosphates; Quantitative analysis; Rate constants; reaction networks; Ribonucleic acid; RNA; Substrates; Water - chemistry; organocatalysis; prebiotic chemistry; peptides; reaction networks; nucleotides

Organisms use enzymes to ensure a flow of substrates through biosynthetic pathways. How the earliest form of life established biosynthetic networks and prevented hydrolysis of intermediates without enzymes is unclear. Organocatalysts may have played the role of enzymes. Quantitative analysis of reac...