Tuning composition and architecture of biomimetic scaffolds for enhanced matrix synthesis by murine cardiomyocytes

• Published in: Journal of biomedical materials research. Part A Vol. 103; no. 2; pp. 693 - 708
• Main Authors: Gishto, Arsela, Farrell, Kurt, Kothapalli, Chandrasekhar R.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.02.2015; Wiley Subscription Services, Inc
• Subjects: Animals; Biomimetic Materials - chemistry; cardiomyocytes; Cells, Cultured; Collagen - chemistry; Collagenases - biosynthesis; elastin; Extracellular Matrix - metabolism; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry; hydrogels; matrix synthesis; Mice; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; nanofibers; Rats; Tissue Inhibitor of Metalloproteinase-1 - biosynthesis; Tissue Scaffolds - chemistry; cardiomyocytes; hydrogels; elastin; nanofibers; matrix synthesis

A major onset of heart failure is myocardial infarction, which causes the myocardium to lose cardiomyocytes and transform into a scar tissue. Since mammalian infarcted cardiac tissue has a limited ability to regenerate, alternative strategies including implantation of tissue‐engineered scaffolds at...