Mass spectrometry-based targeted quantitative proteomics: Achieving sensitive and reproducible detection of proteins
Traditional shotgun proteomics used to detect a mixture of hundreds to thousands of proteins through mass spectrometric analysis, has been the standard approach in research to profile protein content in a biological sample which could lead to the discovery of new (and all) protein candidates with di...
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| Published in | Proteomics (Weinheim) Vol. 12; no. 8; pp. 1093 - 1110 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Blackwell Publishing Ltd
01.04.2012
Wiley Subscription Services, Inc |
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| Online Access | Get full text |
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| Abstract | Traditional shotgun proteomics used to detect a mixture of hundreds to thousands of proteins through mass spectrometric analysis, has been the standard approach in research to profile protein content in a biological sample which could lead to the discovery of new (and all) protein candidates with diagnostic, prognostic, and therapeutic values. In practice, this approach requires significant resources and time, and does not necessarily represent the goal of the researcher who would rather study a subset of such discovered proteins (including their variations or posttranslational modifications) under different biological conditions. In this context, targeted proteomics is playing an increasingly important role in the accurate measurement of protein targets in biological samples in the hope of elucidating the molecular mechanism of cellular function via the understanding of intricate protein networks and pathways. One such (targeted) approach, selected reaction monitoring (or multiple reaction monitoring) mass spectrometry (MRM‐MS), offers the capability of measuring multiple proteins with higher sensitivity and throughput than shotgun proteomics. Developing and validating MRM‐MS‐based assays, however, is an extensive and iterative process, requiring a coordinated and collaborative effort by the scientific community through the sharing of publicly accessible data and datasets, bioinformatic tools, standard operating procedures, and well characterized reagents. |
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| AbstractList | Traditional shotgun proteomics used to detect a mixture of hundreds to thousands of proteins through mass spectrometric analysis, has been the standard approach in research to profile protein content in a biological sample which could lead to the discovery of new (and all) protein candidates with diagnostic, prognostic, and therapeutic values. In practice, this approach requires significant resources and time, and does not necessarily represent the goal of the researcher who would rather study a subset of such discovered proteins (including their variations or posttranslational modifications) under different biological conditions. In this context, targeted proteomics is playing an increasingly important role in the accurate measurement of protein targets in biological samples in the hope of elucidating the molecular mechanism of cellular function via the understanding of intricate protein networks and pathways. One such (targeted) approach, selected reaction monitoring (or multiple reaction monitoring) mass spectrometry (MRM-MS), offers the capability of measuring multiple proteins with higher sensitivity and throughput than shotgun proteomics. Developing and validating MRM-MS-based assays, however, is an extensive and iterative process, requiring a coordinated and collaborative effort by the scientific community through the sharing of publicly accessible data and datasets, bioinformatic tools, standard operating procedures, and well characterized reagents. Traditional shotgun proteomics used to detect a mixture of hundreds to thousands of proteins through mass spectrometric analysis, has been the standard approach in research to profile protein content in a biological sample which could lead to the discovery of new (and all) protein candidates with diagnostic, prognostic, and therapeutic values. In practice, this approach requires significant resources and time, and does not necessarily represent the goal of the researcher who would rather study a subset of such discovered proteins (including their variations or posttranslational modifications) under different biological conditions. In this context, targeted proteomics is playing an increasingly important role in the accurate measurement of protein targets in biological samples in the hope of elucidating the molecular mechanism of cellular function via the understanding of intricate protein networks and pathways. One such (targeted) approach, selected reaction monitoring (or multiple reaction monitoring) mass spectrometry ( MRM ‐ MS ), offers the capability of measuring multiple proteins with higher sensitivity and throughput than shotgun proteomics. Developing and validating MRM ‐ MS ‐based assays, however, is an extensive and iterative process, requiring a coordinated and collaborative effort by the scientific community through the sharing of publicly accessible data and datasets, bioinformatic tools, standard operating procedures, and well characterized reagents. |
| Author | Rodriguez, Henry Boja, Emily S. |
| Author_xml | – sequence: 1 givenname: Emily S. surname: Boja fullname: Boja, Emily S. email: bojae@mail.nih.gov organization: Office of Cancer Clinical Proteomics Research, National Cancer Institute, National Institutes of Health, MD, Bethesda, USA – sequence: 2 givenname: Henry surname: Rodriguez fullname: Rodriguez, Henry |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22577011$$D View this record in MEDLINE/PubMed |
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| Copyright | 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
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| SubjectTerms | Biomarker verification Biomarkers - analysis Databases, Protein High-Throughput Screening Assays Humans Ions Mass spectrometry Mass Spectrometry - instrumentation Mass Spectrometry - methods Mass Spectrometry - standards Multiple reaction monitoring mass spectrometry Posttranslational modifications Protein Processing, Post-Translational Protein quantitation Proteins Proteins - analysis Proteomics Proteomics - instrumentation Proteomics - methods Proteomics - standards Reference Standards Reproducibility of Results Scientific imaging Sensitivity and Specificity Software Systems biology Technology |
| Title | Mass spectrometry-based targeted quantitative proteomics: Achieving sensitive and reproducible detection of proteins |
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