Specificity of IgG subclass antibodies in different clinical manifestations of leprosy
SUMMARY We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL‐I) in the sera of leprosy patients with different clinical manifestations. IgG2 was found to be the predominant antibody to MSE regardless of cl...
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Published in | Clinical and experimental immunology Vol. 88; no. 2; pp. 253 - 257 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.1992
Blackwell |
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Abstract | SUMMARY
We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL‐I) in the sera of leprosy patients with different clinical manifestations. IgG2 was found to be the predominant antibody to MSE regardless of clinical manifestations, and IgG 1 response was mostly seen in lepromatous patients. IgG3 reacted only rarely but IgG4 reacted relatively more in certain clinical groups such as borderline lepromatous and lepromatous with erythema nodosum leprosum (ENL) reaction. Most of the IgG subclass responses to MSE could be accounted for reactivity with LAM, suggesting that LAM is the major immunogen involved in the pathogenesis of leprosy. In contrast to LAM. PGL‐I antigen showed considerably lower reactivities for IgG subclasses. An association between IgG subclass responses and clinical manifestations of leprosy was also seen. Whereas borderline lepromatous patients were found to have significantly higher levels of IgG2 and lgG4 to MSE, lepromatous patients had elevated levels of IgG I and lower levels of IgG2. An interesting observation, however, was the significantly higher levels of IgG2 to LAM in the pure neuritic leprosy patients. |
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AbstractList | We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL-I) in the sera of leprosy patients with different clinical manifestations. IgG2 was found to be the predominant antibody to MSE regardless of clinical manifestations, and IgG1 response was mostly seen in lepromatous patients. IgG3 reacted only rarely but IgG4 reacted relatively more in certain clinical groups such as borderline lepromatous and lepromatous with erythema nodosum leprosum (ENL) reaction. Most of the IgG subclass responses to MSE could be accounted for reactivity with LAM, suggesting that LAM is the major immunogen involved in the pathogenesis of leprosy. In contrast to LAM, PGL-I antigen showed considerably lower reactivities for IgG subclasses. An association between IgG subclass responses and clinical manifestations of leprosy was also seen. Whereas borderline lepromatous patients were found to have significantly higher levels of IgG2 and IgG4 to MSE, lepromatous patients had elevated levels of IgG1 and lower levels of IgG2. An interesting observation, however, was the significantly higher levels of IgG2 to LAM in the pure neuritic leprosy patients. SUMMARY We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL-I) in the sera of leprosy patients with different clinical manifestations. IgG2 was found to be the predominant antibody to MSE regardless of clinical manifestations, and IgG 1 response was mostly seen in lepromatous patients. IgG3 reacted only rarely but IgG4 reacted relatively more in certain clinical groups such as borderline lepromatous and lepromatous with erythema nodosum leprosum (ENL) reaction. Most of the IgG subclass responses to MSE could be accounted for reactivity with LAM, suggesting that LAM is the major immunogen involved in the pathogenesis of leprosy. In contrast to LAM. PGL-I antigen showed considerably lower reactivities for IgG subclasses. An association between IgG subclass responses and clinical manifestations of leprosy was also seen. Whereas borderline lepromatous patients were found to have significantly higher levels of IgG2 and lgG4 to MSE, lepromatous patients had elevated levels of IgG I and lower levels of IgG2. An interesting observation, however, was the significantly higher levels of IgG2 to LAM in the pure neuritic leprosy patients. |
Author | DHANDAYUTHAPANI, S. IZUMI, S. BHATIA, V. N. ANANDAN, D. |
AuthorAffiliation | Central Leprosy Teaching and Research Institute, Chengalpattu, India |
AuthorAffiliation_xml | – name: Central Leprosy Teaching and Research Institute, Chengalpattu, India |
Author_xml | – sequence: 1 givenname: S. surname: DHANDAYUTHAPANI fullname: DHANDAYUTHAPANI, S. – sequence: 2 givenname: S. surname: IZUMI fullname: IZUMI, S. – sequence: 3 givenname: D. surname: ANANDAN fullname: ANANDAN, D. – sequence: 4 givenname: V. N. surname: BHATIA fullname: BHATIA, V. N. |
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Cites_doi | 10.1111/j.1365-2249.1990.tb06443.x 10.1128/jcm.26.12.2474-2479.1988 10.1146/annurev.mi.41.100187.003241 10.1128/iai.36.3.885-892.1982 10.1111/j.1365-2249.1990.tb05339.x 10.1128/iai.56.5.1232-1236.1988 10.1111/j.1600-065X.1984.tb00493.x 10.1128/CMR.1.3.330 10.1111/1523-1747.ep12354963 10.1128/iai.42.1.237-244.1983 10.4049/jimmunol.138.9.3028 10.4049/jimmunol.134.4.2707 10.4049/jimmunol.139.8.2794 10.4049/jimmunol.142.12.4422 10.1128/iai.55.11.2860-2863.1987 10.3181/00379727-140-36612 |
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Keywords | Human Skin disease Mycobacterium leprae IgG Leprosy Quantization Isotype IgG1 Serology Mycobacterial infection IgG2 Infection Mycobacteriales Bacteriosis Mycobacteriaceae Bacteria Serum Actinomycetes |
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Snippet | SUMMARY
We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL‐I)... We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL-I) in the... SUMMARY We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL-I)... |
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SubjectTerms | Analysis of Variance Antibodies, Bacterial - classification Bacterial diseases Biological and medical sciences clinical manifestations Enzyme-Linked Immunosorbent Assay Human bacterial diseases Humans IgG subclasses Immunoglobulin G - classification Infectious diseases Leprosy Leprosy - immunology Leprosy - physiopathology Medical sciences Mycobacterium leprae - immunology Tropical bacterial diseases |
Title | Specificity of IgG subclass antibodies in different clinical manifestations of leprosy |
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