Fatty Acid Chain Shortening by a Fungal Peroxygenase

• Published in: Chemistry : a European journal Vol. 23; no. 67; pp. 16985 - 16989
• Main Authors: Olmedo, Andrés, Río, José C. del, Kiebist, Jan, Ullrich, René, Hofrichter, Martin, Scheibner, Katrin, Martínez, Angel T., Gutiérrez, Ana
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.12.2017; John Wiley and Sons Inc
• Subjects: Agrocybe - enzymology; Carboxylic acids; Catalysis; chain shortening; Chains; Chemistry; Communication; Communications; Crystal structure; Decarboxylation; Dicarboxylic acids; enzymes; Fatty acids; Fatty Acids - chemistry; Fungal Proteins - chemistry; Heme; Heme - chemistry; Hydrogen - chemistry; Hydrogen peroxide; Kinetics; Mixed Function Oxygenases - chemistry; Molecular Structure; Oxidation; Oxidation-Reduction; Oxygen - chemistry; Thermodynamics; oxidation; enzymes; chain shortening; carboxylic acids; hydrogen peroxide

A recently discovered peroxygenase from the fungus Marasmius rotula (MroUPO) is able to catalyze the progressive one‐carbon shortening of medium and long‐chain mono‐ and dicarboxylic acids by itself alone, in the presence of H2O2. The mechanism, analyzed using H218O2, starts with an α‐oxidation cata...