A common variant in the patatin‐like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

• Published in: Hepatology (Baltimore, Md.) Vol. 52; no. 4; pp. 1281 - 1290
• Main Authors: Santoro, Nicola, Kursawe, Romy, D'Adamo, Ebe, Dykas, Daniel J., Zhang, Clarence K., Bale, Allen E., Calí, Anna M., Narayan, Deepak, Shaw, Melissa M., Pierpont, Bridget, Savoye, Mary, Lartaud, Derek, Eldrich, Samuel, Cushman, Samuel W., Zhao, Hongyu, Shulman, Gerald I., Caprio, Sonia
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2010; Wiley; Wolters Kluwer Health, Inc
• Subjects: Adipose Tissue - cytology; Adolescent; African Americans; Biological and medical sciences; Cell Size; Child; Fatty Liver - genetics; Fatty Liver - pathology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression; Gene Frequency; Genes; Genotype; Humans; Lipase - genetics; Liver - metabolism; Liver diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metabolic diseases; Obesity; Obesity - genetics; Other diseases. Semiology; Polymorphism, Single Nucleotide; Human; Obesity; Enzyme; Nutrition disorder; Hepatic disease; Esterases; Phospholipase; Fatty liver; Adolescent; Gastroenterology; Hydrolases; Digestive diseases; Child; Nutritional status

The genetic factors associated with susceptibility to nonalcoholic fatty liver disease (NAFLD) in pediatric obesity remain largely unknown. Recently, a nonsynonymous single‐nucleotide polymorphism (rs738409), in the patatin‐like phospholipase 3 gene (PNPLA3) has been associated with hepatic steatosi...