Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro

• Published in: Parasite immunology Vol. 33; no. 10; pp. 572 - 582
• Main Authors: ILIC, N., WORTHINGTON, J. J., GRUDEN‐MOVSESIJAN, A., TRAVIS, M. A., SOFRONIC‐MILOSAVLJEVIC, L., GRENCIS, R. K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2011
• Subjects: Animals; Antigens, Helminth - immunology; Bone marrow; CD4 antigen; Cell proliferation; Cytokines - metabolism; Dendritic cells; Dendritic Cells - immunology; Developmental stages; Female; Forkhead Transcription Factors - analysis; Foxp3 protein; Foxp3+ Treg cells; gamma -Interferon; Helper cells; Immunoregulation; Infection; Interleukin 10; Interleukin 13; Interleukin 4; Interleukin 9; Lymphocytes T; Mice; Mice, Inbred C57BL; Original; Parasites; Polarization; T-Lymphocyte Subsets - chemistry; T-Lymphocyte Subsets - immunology; Th1/Th2 polarization; Trichinella spiralis; Trichinella spiralis - immunology

Summary Many parasitic helminth infections induce Th2‐type immune responses and engage the regulatory network. In this study, we specifically investigated the influence of antigens derived from different life stages of the helminth Trichinella spiralis on the polarization of naive CD4+ T cells by de...