Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte‐derived cells

• Published in: Molecular microbiology Vol. 61; no. 2; pp. 324 - 337
• Main Authors: Maldonado‐Arocho, Francisco J., Fulcher, Jennifer A., Lee, Benhur, Bradley, Kenneth A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2006; Blackwell Science
• Subjects: Adenylyl Cyclases - pharmacology; Animals; Anthrax; Antigens, Bacterial - drug effects; Antigens, Bacterial - metabolism; Bacillus anthracis; Bacterial Toxins - metabolism; Biological and medical sciences; Cell Lineage; Cells, Cultured; Dendritic Cells - drug effects; Dendritic Cells - metabolism; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation - drug effects; Humans; Immunology; Macrophages - drug effects; Macrophages - metabolism; Membrane Proteins - drug effects; Membrane Proteins - genetics; Mice; Microbiology; Molecular biology; Monocytes - drug effects; Monocytes - metabolism; Monocytes - microbiology; Neoplasm Proteins - drug effects; Neoplasm Proteins - genetics; Receptors, Cell Surface - drug effects; Receptors, Cell Surface - genetics; Receptors, Peptide - genetics; Receptors, Peptide - metabolism; RNA, Messenger - metabolism; Signal transduction; Infection; Bacillus anthracis; Toxin; Bacillales; Microbiology; Monocyte; Anthrax; Bacteriosis; Bacteria; Bacillaceae

Summary Bacillus anthracis, the causative agent of anthrax, secretes two bipartite toxins that help the bacterium evade the immune system and contribute directly to pathogenesis. Both toxin catalytic moieties, lethal factor (LF) and oedema factor (OF), are internalized into the host‐cell cytosol by...