Differential Effects of Donepezil on Methamphetamine and Cocaine Dependencies

• Published in: Annals of the New York Academy of Sciences Vol. 1074; no. 1; pp. 418 - 426
• Main Authors: TAKAMATSU, YUKIO, YAMANISHI, YOSHIHARU, HAGINO, YOKO, YAMAMOTO, HIDEKO, IKEDA, KAZUTAKA
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.08.2006
• Subjects: Amphetamine-Related Disorders - drug therapy; Animals; Behavior, Animal - drug effects; cocaine; Cocaine-Related Disorders - drug therapy; conditioned place preference; Conditioning (Psychology); donepezil; Indans - pharmacology; Male; methamphetamine; Mice; Mice, Inbred C57BL; Motor Activity - drug effects; Piperidines - pharmacology; sensitization

:  Donepezil, a choline esterase inhibitor, has been widely used as a medicine for Alzheimer's disease. Recently, a study showed that donepezil inhibited addictive behaviors induced by cocaine, including cocaine‐conditioned place preference (CPP) and locomotor sensitization to cocaine. In the p...