Serum miRNAs panel (miR-16-2, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer

• Published in: Scientific reports Vol. 5; no. 1; p. 17942
• Main Authors: Zhang, Yujuan, Zhang, Donghong, Wang, Fei, Xu, Danfei, Guo, Ye, Cui, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.12.2015; Nature Publishing Group
• Subjects: 13/109; 13/2; 49/47; 64/60; 692/53/2421; 692/699/67/1857; Adult; Animals; Biomarkers, Tumor; Breast cancer; Cervical cancer; Cervix; Disease Models, Animal; Early Detection of Cancer; Female; Gene Expression Profiling; Genes, Tumor Suppressor; Human papillomavirus; Humanities and Social Sciences; Humans; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miRNA; multidisciplinary; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Ovarian cancer; Ovarian Neoplasms - genetics; Polymerase chain reaction; Prognosis; Science; Sensitivity and Specificity; Transcription; Tumorigenesis; Uterine Cervical Neoplasms - blood; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - genetics

miRNAs have been established as critical layer of regulation during tumorigenesis; extracellular miRNAs are extraordinarily stable; and, quantitative reverse transcript polymerase chain reaction (qRT-PCR) provides a sensitive platform for quantifying miRNAs with a broad dynamic range. Herein, we aim...