Mesenchymal Stem Cells Exploit Extracellular Matrix as Mechanotransducer

• Published in: Scientific reports Vol. 3; no. 1; p. 2425
• Main Authors: Li, Bojun, Moshfegh, Cameron, Lin, Zhe, Albuschies, Jörg, Vogel, Viola
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.08.2013; Nature Publishing Group
• Subjects: 631/532; 631/57; 631/61; 631/80; Cell Differentiation - physiology; Cells, Cultured; Contractility; Epidermal growth factor; Extracellular matrix; Extracellular Matrix - physiology; Extracellular Matrix Proteins - metabolism; Fibers; Fibrils; Fibronectin; Fibronectins - physiology; Gels; Humanities and Social Sciences; Humans; Integrins; Mechanotransduction, Cellular - physiology; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - physiology; Mesenchyme; multidisciplinary; Osteogenesis; Osteogenesis - physiology; Physical properties; Science; Stem cells

While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into biochemical signals remain unknown. Here we show that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracel...