Mesenchymal Stem Cells Exploit Extracellular Matrix as Mechanotransducer

While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into biochemical signals remain unknown. Here we show that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracel...

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Published inScientific reports Vol. 3; no. 1; p. 2425
Main Authors Li, Bojun, Moshfegh, Cameron, Lin, Zhe, Albuschies, Jörg, Vogel, Viola
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.08.2013
Nature Publishing Group
Subjects
631/532
631/57
631/61
631/80
Cell Differentiation - physiology
Cells, Cultured
Contractility
Epidermal growth factor
Extracellular matrix
Extracellular Matrix - physiology
Extracellular Matrix Proteins - metabolism
Fibers
Fibrils
Fibronectin
Fibronectins - physiology
Gels
Humanities and Social Sciences
Humans
Integrins
Mechanotransduction, Cellular - physiology
Mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - physiology
Mesenchyme
multidisciplinary
Osteogenesis
Osteogenesis - physiology
Physical properties
Science
Stem cells
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Abstract While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into biochemical signals remain unknown. Here we show that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracellular matrix (ECM) fibrils within 24 hours. hMSCs pro-actively pull on newly assembled fibronectin ECM fibrils and the fibers are more stretched on rigid than on soft fibronectin-coated polyacrylamide gels. Culturing hMSCs on single stretched fibronectin fibers upregulates hMSC osteogenesis. Osteogenesis was increased when αvβ3 integrins were blocked on relaxed fibronectin fibers and decreased when α5β1 integrins were blocked or when epidermal growth factor (EGF) receptor signaling was inhibited on stretched fibronectin fibers. This suggests that hMSCs utilize their own contractile forces to translate environmental cues into differential biochemical signals by stretching fibronectin fibrils. Mechanoregulation of fibronectin fibrils may thus serve as check point to regulate hMSC osteogenesis.
AbstractList While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into biochemical signals remain unknown. Here we show that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracellular matrix (ECM) fibrils within 24 hours. hMSCs pro-actively pull on newly assembled fibronectin ECM fibrils, and the fibers are more stretched on rigid than on soft fibronectin-coated polyacrylamide gels. Culturing hMSCs on single stretched fibronectin fibers upregulates hMSC osteogenesis. Osteogenesis was increased when αvβ3 integrins were blocked on relaxed fibronectin fibers, and decreased when α5β1 integrins were blocked or when epidermal growth factor (EGF) receptor signaling was inhibited on stretched fibronectin fibers. This suggests that hMSCs utilize their own contractile forces to translate environmental cues into differential biochemical signals by stretching fibronectin fibrils. Mechanoregulation of fibronectin fibrils may thus serve as check point to regulate hMSC osteogenesis.
While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into biochemical signals remain unknown. Here we show that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracellular matrix (ECM) fibrils within 24 hours. hMSCs pro-actively pull on newly assembled fibronectin ECM fibrils, and the fibers are more stretched on rigid than on soft fibronectin-coated polyacrylamide gels. Culturing hMSCs on single stretched fibronectin fibers upregulates hMSC osteogenesis. Osteogenesis was increased when αvβ3 integrins were blocked on relaxed fibronectin fibers, and decreased when α5β1 integrins were blocked or when epidermal growth factor (EGF) receptor signaling was inhibited on stretched fibronectin fibers. This suggests that hMSCs utilize their own contractile forces to translate environmental cues into differential biochemical signals by stretching fibronectin fibrils. Mechanoregulation of fibronectin fibrils may thus serve as check point to regulate hMSC osteogenesis.While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into biochemical signals remain unknown. Here we show that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracellular matrix (ECM) fibrils within 24 hours. hMSCs pro-actively pull on newly assembled fibronectin ECM fibrils, and the fibers are more stretched on rigid than on soft fibronectin-coated polyacrylamide gels. Culturing hMSCs on single stretched fibronectin fibers upregulates hMSC osteogenesis. Osteogenesis was increased when αvβ3 integrins were blocked on relaxed fibronectin fibers, and decreased when α5β1 integrins were blocked or when epidermal growth factor (EGF) receptor signaling was inhibited on stretched fibronectin fibers. This suggests that hMSCs utilize their own contractile forces to translate environmental cues into differential biochemical signals by stretching fibronectin fibrils. Mechanoregulation of fibronectin fibrils may thus serve as check point to regulate hMSC osteogenesis.
ArticleNumber 2425
Author Albuschies, Jörg
Li, Bojun
Lin, Zhe
Vogel, Viola
Moshfegh, Cameron
Author_xml – sequence: 1
  givenname: Bojun
  surname: Li
  fullname: Li, Bojun
  organization: Department of Health Sciences and Technology, ETH Zurich
– sequence: 2
  givenname: Cameron
  surname: Moshfegh
  fullname: Moshfegh, Cameron
  organization: Department of Health Sciences and Technology, ETH Zurich
– sequence: 3
  givenname: Zhe
  surname: Lin
  fullname: Lin, Zhe
  organization: Department of Health Sciences and Technology, ETH Zurich
– sequence: 4
  givenname: Jörg
  surname: Albuschies
  fullname: Albuschies, Jörg
  organization: Department of Health Sciences and Technology, ETH Zurich
– sequence: 5
  givenname: Viola
  surname: Vogel
  fullname: Vogel, Viola
  organization: Department of Health Sciences and Technology, ETH Zurich
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23939587$$D View this record in MEDLINE/PubMed
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Snippet While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into...
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SubjectTerms 631/532
631/57
631/61
631/80
Cell Differentiation - physiology
Cells, Cultured
Contractility
Epidermal growth factor
Extracellular matrix
Extracellular Matrix - physiology
Extracellular Matrix Proteins - metabolism
Fibers
Fibrils
Fibronectin
Fibronectins - physiology
Gels
Humanities and Social Sciences
Humans
Integrins
Mechanotransduction, Cellular - physiology
Mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - physiology
Mesenchyme
multidisciplinary
Osteogenesis
Osteogenesis - physiology
Physical properties
Science
Stem cells
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Title Mesenchymal Stem Cells Exploit Extracellular Matrix as Mechanotransducer
URI https://link.springer.com/article/10.1038/srep02425
https://www.ncbi.nlm.nih.gov/pubmed/23939587
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Volume 3
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