Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus

• Published in: Scientific reports Vol. 6; no. 1; p. 22341
• Main Authors: Reynolds, John A., Haque, Sahena, Williamson, Kate, Ray, David W., Alexander, M. Yvonne, Bruce, Ian N.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2016; Nature Publishing Group
• Subjects: 13/106; 13/51; 38/77; 692/308/575; 692/4019/592/16; 692/4023/1670/1613; Adult; Autoimmune diseases; Calcitriol - pharmacology; Cardiovascular diseases; Cell Adhesion - drug effects; Cell Count; Cell Differentiation - drug effects; Cell Movement - drug effects; Chemokine CXCL10 - metabolism; Down-Regulation - drug effects; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Health risks; Humanities and Social Sciences; Humans; Immunology; Interferons - metabolism; Lupus; Lupus Erythematosus, Systemic - metabolism; Lupus Erythematosus, Systemic - physiopathology; Middle Aged; Models, Biological; multidisciplinary; Myeloid Cells - drug effects; Myeloid Cells - pathology; Neovascularization, Physiologic - drug effects; Nitric Oxide Synthase Type III - metabolism; Phenotype; Science; Systemic lupus erythematosus; Vitamin D; Vitamin D - pharmacology

Patients with systemic lupus erythematosus (SLE) have accelerated cardiovascular disease and dysfunctional endothelial repair mechanisms. Myeloid angiogenic cells (MACs), derived from circulating monocytes, augment vascular repair by paracrine secretion of pro-angiogenic factors. We observed that SL...