Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection

• Published in: Cell Vol. 177; no. 6; pp. 1566 - 1582.e17
• Main Authors: Davis, Carl W., Jackson, Katherine J.L., McElroy, Anita K., Halfmann, Peter, Huang, Jessica, Chennareddy, Chakravarthy, Piper, Ashley E., Leung, Yvonne, Albariño, César G., Crozier, Ian, Ellebedy, Ali H., Sidney, John, Sette, Alessandro, Yu, Tianwei, Nielsen, Sandra C.A., Goff, Arthur J., Spiropoulou, Christina F., Saphire, Erica Ollman, Cavet, Guy, Kawaoka, Yoshihiro, Mehta, Aneesh K., Glass, Pamela J., Boyd, Scott D., Ahmed, Rafi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.05.2019; Cell Press
• Subjects: Adult; Amino Acid Sequence - genetics; Animals; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - isolation & purification; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody evolution; B cell repertoire; B-Lymphocytes - metabolism; B-Lymphocytes - physiology; Chlorocebus aethiops; Ebola; Ebola Vaccines - immunology; Ebolavirus - genetics; Ebolavirus - metabolism; Ebolavirus - pathogenicity; Epitopes - blood; Female; Glycoproteins - genetics; Hemorrhagic Fever, Ebola - immunology; Hemorrhagic Fever, Ebola - metabolism; Hemorrhagic Fever, Ebola - virology; Humans; IgG subclass; Immunoglobulin G - immunology; Jurkat Cells; Longitudinal Studies; Male; Mice; Mice, Inbred BALB C; public clonotype; Survivors; Vero Cells; Viral Envelope Proteins - genetics; antibody evolution; B cell repertoire; Ebola; IgG subclass; public clonotype

Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1...