D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease

• Published in: Cellular and molecular gastroenterology and hepatology Vol. 16; no. 6; pp. 1011 - 1031
• Main Authors: Umeda, Satoko, Sujino, Tomohisa, Miyamoto, Kentaro, Yoshimatsu, Yusuke, Harada, Yosuke, Nishiyama, Keita, Aoto, Yoshimasa, Adachi, Keika, Hayashi, Naoki, Amafuji, Kimiko, Moritoki, Nobuko, Shibata, Shinsuke, Sasaki, Nobuo, Mita, Masashi, Tanemoto, Shun, Ono, Keiko, Mikami, Yohei, Sasabe, Jumpei, Takabayashi, Kaoru, Hosoe, Naoki, Suzuki, Toshihiko, Sato, Toshiro, Atarashi, Koji, Teratani, Toshiaki, Ogata, Haruhiko, Nakamoto, Nobuhiro, Shiomi, Daisuke, Ashida, Hiroshi, Kanai, Takanori
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023; Elsevier
• Subjects: Alanine; Amino Acids; Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Cholangitis - drug therapy; Colitis - chemically induced; Colitis - drug therapy; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; D-Amino Acid; Escherichia coli; Humans; IBD; Inflammatory Bowel Diseases - drug therapy; Liver Cholangitis; Mice; Microbiome; Original Research; Proteobacteria; D-Amino Acid; IBD; ▪; Liver Cholangitis; Microbiome; K. pneumoniae; ftsZ; Ulcerative Colitis; E.coli; Colitis; Inflammatory Bowel Disease; Antibiotic-resistant Bacteria

D-amino acids, the chiral counterparts of protein L-amino acids, were primarily produced and utilized by microbes, including those in the human gut. However, little was known about how orally administered or microbe-derived D-amino acids affected the gut microbial community or gut disease progressio...