Global metabolomics reveals potential urinary biomarkers of esophageal squamous cell carcinoma for diagnosis and staging

• Published in: Scientific reports Vol. 6; no. 1; p. 35010
• Main Authors: Xu, Jing, Chen, Yanhua, Zhang, Ruiping, He, Jiuming, Song, Yongmei, Wang, Jingbo, Wang, Huiqing, Wang, Luhua, Zhan, Qimin, Abliz, Zeper
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.10.2016; Nature Publishing Group
• Subjects: 639/638/11/296; 692/53/2421; Aged; Amino Acids - urine; Biomarkers; Biomarkers, Tumor - urine; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - urine; Chromatography, High Pressure Liquid; Data processing; Esophageal cancer; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - urine; Esophageal Squamous Cell Carcinoma; Esophagus; Fatty Acids - urine; Humanities and Social Sciences; Humans; Liquid chromatography; Male; Mass spectroscopy; Metabolic pathways; Metabolomics; Metabolomics - methods; Middle Aged; multidisciplinary; Multivariate Analysis; Neoplasm Staging; Oxidation; Purines; Pyrimidines; Science; Squamous cell carcinoma; Tandem Mass Spectrometry; Urine

We performed a metabolomics study using liquid chromatography-mass spectrometry (LC-MS) combined with multivariate data analysis (MVDA) to discriminate global urine profiles in urine samples from esophageal squamous cell carcinoma (ESCC) patients and healthy controls (NC). Our work evaluated the fea...