Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing

• Published in: Scientific reports Vol. 6; no. 1; p. 21722
• Main Authors: Ahn, Matae, Cui, Jie, Irving, Aaron T., Wang, Lin-Fa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.02.2016; Nature Publishing Group
• Subjects: 631/181/2474; 631/208/182; Animals; Base Sequence; Bats; Chiroptera - genetics; Conserved Sequence; Deoxyribonucleic acid; Divergence; DNA; Evolution, Molecular; Genetic Loci; Genomes; Genomic analysis; Humanities and Social Sciences; Inflammasomes; Inflammasomes - physiology; Interferon; Mammals; multidisciplinary; Pyrin Domain; Science; Science (multidisciplinary); Sensors; Sequence Analysis, DNA; Species

Recent genomic analysis of two bat species ( Pteropus alecto and Myotis davidii ) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessme...