Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing
Recent genomic analysis of two bat species ( Pteropus alecto and Myotis davidii ) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessme...
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| Published in | Scientific reports Vol. 6; no. 1; p. 21722 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
24.02.2016
Nature Publishing Group |
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| Abstract | Recent genomic analysis of two bat species (
Pteropus alecto
and
Myotis davidii
) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat species. We confirmed the complete loss of this gene family, with only a truncated
AIM2
remaining in one species (
Pteronotus parnellii
). Divergence of the PYHIN gene loci between the bat lineages infers different loss-of-function histories during bat evolution. While all other major groups of placental mammals have at least one gene member, only bats have lost the entire family. This removal of inflammasome DNA sensors may indicate an important adaptation that is flight-induced and related, at least in part, to pathogen-host co-existence. |
|---|---|
| AbstractList | Recent genomic analysis of two bat species (Pteropus alecto and Myotis davidii) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat species. We confirmed the complete loss of this gene family, with only a truncated AIM2 remaining in one species (Pteronotus parnellii). Divergence of the PYHIN gene loci between the bat lineages infers different loss-of-function histories during bat evolution. While all other major groups of placental mammals have at least one gene member, only bats have lost the entire family. This removal of inflammasome DNA sensors may indicate an important adaptation that is flight-induced and related, at least in part, to pathogen-host co-existence. Recent genomic analysis of two bat species ( Pteropus alecto and Myotis davidii ) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat species. We confirmed the complete loss of this gene family, with only a truncated AIM2 remaining in one species ( Pteronotus parnellii ). Divergence of the PYHIN gene loci between the bat lineages infers different loss-of-function histories during bat evolution. While all other major groups of placental mammals have at least one gene member, only bats have lost the entire family. This removal of inflammasome DNA sensors may indicate an important adaptation that is flight-induced and related, at least in part, to pathogen-host co-existence. |
| ArticleNumber | 21722 |
| Author | Cui, Jie Ahn, Matae Wang, Lin-Fa Irving, Aaron T. |
| Author_xml | – sequence: 1 givenname: Matae surname: Ahn fullname: Ahn, Matae organization: Programme in Emerging Infectious Diseases, Duke–National University of Singapore Medical School – sequence: 2 givenname: Jie surname: Cui fullname: Cui, Jie organization: Programme in Emerging Infectious Diseases, Duke–National University of Singapore Medical School – sequence: 3 givenname: Aaron T. surname: Irving fullname: Irving, Aaron T. organization: Programme in Emerging Infectious Diseases, Duke–National University of Singapore Medical School – sequence: 4 givenname: Lin-Fa surname: Wang fullname: Wang, Lin-Fa email: linfa.wang@duke-nus.edu.sg organization: Programme in Emerging Infectious Diseases, Duke–National University of Singapore Medical School |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26906452$$D View this record in MEDLINE/PubMed |
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| Copyright | The Author(s) 2016 Copyright Nature Publishing Group Feb 2016 Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited |
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| Snippet | Recent genomic analysis of two bat species (
Pteropus alecto
and
Myotis davidii
) revealed the absence of the PYHIN gene family. This family is recognized as... Recent genomic analysis of two bat species (Pteropus alecto and Myotis davidii) revealed the absence of the PYHIN gene family. This family is recognized as... |
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| SubjectTerms | 631/181/2474 631/208/182 Animals Base Sequence Bats Chiroptera - genetics Conserved Sequence Deoxyribonucleic acid Divergence DNA Evolution, Molecular Genetic Loci Genomes Genomic analysis Humanities and Social Sciences Inflammasomes Inflammasomes - physiology Interferon Mammals multidisciplinary Pyrin Domain Science Science (multidisciplinary) Sensors Sequence Analysis, DNA Species |
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| Title | Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing |
| URI | https://link.springer.com/article/10.1038/srep21722 https://www.ncbi.nlm.nih.gov/pubmed/26906452 https://www.proquest.com/docview/1898963391 https://search.proquest.com/docview/1768560788 https://pubmed.ncbi.nlm.nih.gov/PMC4764838 |
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