Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

• Published in: Scientific reports Vol. 5; no. 1; p. 12393
• Main Authors: Li, Xinzhong, Long, Jintao, He, Taigang, Belshaw, Robert, Scott, James
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.07.2015; Nature Publishing Group
• Subjects: 631/114; 692/617/375/365/1283; Alzheimer Disease - metabolism; Alzheimer's disease; Atrophy; Brain - metabolism; Calcium Signaling; Calcium signalling; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation; Genomics - methods; Humanities and Social Sciences; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mitochondria; multidisciplinary; Nerve Tissue Proteins - metabolism; Neurodegenerative diseases; NF-κB protein; Nitric oxide; Phosphatidylinositol; Protein interaction; Protein Interaction Mapping - methods; Proteins; Proteome - metabolism; Reactive oxygen species; Science; Signal transduction; Stat3 protein; Systems Integration; TLR4 protein; Toll-like receptors

Previous studies have evaluated gene expression in Alzheimer’s disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied. Here we have implemented a novel meta-analysis approach to identify differentially expressed genes (DEGs) in published data...