NF-κB signaling mediates homeostatic maturation of new T cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 9; p. 3212
• Main Authors: Silva, Ana, Cornish, Georgina, Ley, Steven C., Seddon, Benedict
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 04.03.2014; National Acad Sciences
• Series: PNAS Plus
• Subjects: adaptive immunity; Animals; Biological Sciences; cell division; Flow Cytometry; Gene Expression Regulation - immunology; Homeostasis - immunology; Immunoblotting; interleukin-7; Mice; Mice, Transgenic; NF-kappa B - immunology; NF-kappa B - metabolism; PNAS Plus; PNAS Plus: Significance Statements; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-7 - metabolism; signal transduction; Signal Transduction - immunology; T-lymphocytes; T-Lymphocytes - cytology; T-Lymphocytes - immunology; thymus gland; Thymus Gland - cytology; Thymus Gland - immunology; transcription factor NF-kappa B

Interleukin (IL)-7 is critical for the maintenance of the peripheral T-cell compartment of the adaptive immune system. Our study identifies a role for the Nuclear Factor κ-B (NF-κB) signalling pathway in the control of IL-7 receptor expression by T cells. Following thymic selection, new T cells spec...