Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old

• Published in: Journal of Alzheimer's disease Vol. 79; no. 1; p. 389
• Main Authors: Beach, Thomas G, Malek-Ahmadi, Michael
• Format: Journal Article
• Language: English
• Published: United States 01.01.2021
• Subjects: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease - epidemiology; Alzheimer Disease - pathology; Cerebral Hemorrhage - epidemiology; Cerebral Hemorrhage - pathology; Cerebral Infarction - epidemiology; Cerebral Infarction - pathology; Comorbidity; Female; Hippocampus - pathology; Humans; Lewy Body Disease - epidemiology; Lewy Body Disease - pathology; Male; Middle Aged; Neurodegenerative Diseases - epidemiology; Neurodegenerative Diseases - pathology; Sclerosis; Tauopathies - epidemiology; Tauopathies - pathology; TDP-43 Proteinopathies - epidemiology; TDP-43 Proteinopathies - pathology; white matter; tau; Cerebrovascular; infarct; TDP-43; Lewy bodies

Clinicopathological studies have demonstrated that Alzheimer's disease dementia (ADD) is often accompanied by clinically undetectable comorbid neurodegenerative and cerebrovascular disease that alter the rate of cognitive decline. Aside from causing increased variability in clinical response, i...