Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

• Published in: Scientific reports Vol. 3; no. 1; p. 1197
• Main Authors: Katsuda, Takeshi, Tsuchiya, Reiko, Kosaka, Nobuyoshi, Yoshioka, Yusuke, Takagaki, Kentaro, Oki, Katsuyuki, Takeshita, Fumitaka, Sakai, Yasuyuki, Kuroda, Masahiko, Ochiya, Takahiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2013; Nature Publishing Group
• Subjects: 631/378/340; 631/45/607/468; 631/532/2074; 631/61/2297; Adipose tissue; Adipose Tissue - cytology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Bone marrow; Cells, Cultured; Exosomes; Exosomes - metabolism; Fluorescent Dyes - chemistry; Gene transfer; Humanities and Social Sciences; Humans; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - secretion; Mesenchyme; multidisciplinary; Nep gene; Neprilysin; Neprilysin - genetics; Neprilysin - metabolism; Neprilysin - secretion; Neurodegenerative diseases; Peptide Fragments - metabolism; Recombinant Proteins - biosynthesis; Recombinant Proteins - genetics; Science; Skin & tissue grafts; Stem cells; β-Amyloid

Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) in the brain because of an imbalance between Aβ production and clearance. Neprilysin (NEP) is the most important Aβ-degrading enzyme in the brain. Thus, researchers have explored virus-mediated NEP gene deli...