Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro

• Published in: Frontiers in immunology Vol. 8; p. 2010
• Main Authors: Olvera, Alex, Martinez, Javier P., Casadellà, Maria, Llano, Anuska, Rosás, Míriam, Mothe, Beatriz, Ruiz-Riol, Marta, Arsequell, Gemma, Valencia, Gregorio, Noguera-Julian, Marc, Paredes, Roger, Meyerhans, Andreas, Brander, Christian
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 26.01.2018; Frontiers Media S.A
• Subjects: Benzyl-2-acetamido-2-deoxy-α-d-galactopyranoside; Human immunodeficiency virus-1; Immunology; Infectivity; O-glycosylation; Replication; Viral outgrowth; human immunodeficiency virus-1; replication; O-glycosylation; benzyl-2-acetamido-2-deoxy-α-d-galactopyranoside; infectivity; viral outgrowth

Glycosylation of host and viral proteins is an important posttranslational modification needed to ensure correct function of glycoproteins. For this reason, we asked whether inhibition of O-glycosylation during human immunodeficiency virus (HIV) replication could affect HIV infectivity and replicati...