Comparative Analysis of Antimicrobial Efficacy of Sodium Hypochlorite and Chlorhexidine as Irrigants in Root Canal Therapy
ABSTRACT Objective: This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)". Materials and Methods: In this ran...
Saved in:
| Published in | Journal of pharmacy & bioallied science Vol. 17; no. Suppl 1; pp. S454 - S456 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Wolters Kluwer - Medknow
01.05.2025
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications |
| Edition | 2 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0976-4879 0975-7406 |
| DOI | 10.4103/jpbs.jpbs_1422_24 |
Cover
Loading…
| Abstract | ABSTRACT
Objective:
This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)".
Materials and Methods:
In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5% NaOCl as the irrigant, while Group B received 2% CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting "colony-forming units (CFUs)" following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05.
Results:
Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96% reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86% reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant.
Conclusion:
Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. |
|---|---|
| AbstractList | Objective: This research aims to analyze the antimicrobial efficacy of “sodium hypochlorite (NaOCl)” and “chlorhexidine (CHX)” as canal irrigants, evaluating their effects on bacterial load during “Root canal treatment (RCT)”. Materials and Methods: In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5% NaOCl as the irrigant, while Group B received 2% CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting “colony-forming units (CFUs)” following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05. Results: Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96% reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86% reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant. Conclusion: Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. ABSTRACT Objective: This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)". Materials and Methods: In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5% NaOCl as the irrigant, while Group B received 2% CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting "colony-forming units (CFUs)" following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05. Results: Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96% reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86% reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant. Conclusion: Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)". In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5% NaOCl as the irrigant, while Group B received 2% CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting "colony-forming units (CFUs)" following bacterial culture. Statistical analyzes were conducted using paired -tests and ANOVA, with a significance level of < 0.05. Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96% reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86% reduction. The difference in bacterial reduction between the two groups was statistically significant ( < 0.01), indicating that NaOCl was more effective than CHX as an irrigant. Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)".ObjectiveThis research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)".In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5% NaOCl as the irrigant, while Group B received 2% CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting "colony-forming units (CFUs)" following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05.Materials and MethodsIn this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5% NaOCl as the irrigant, while Group B received 2% CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting "colony-forming units (CFUs)" following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05.Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96% reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86% reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant.ResultsBoth NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96% reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86% reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant.Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts.ConclusionSodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. ABSTRACTObjective:This research aims to analyze the antimicrobial efficacy of “sodium hypochlorite (NaOCl)” and “chlorhexidine (CHX)” as canal irrigants, evaluating their effects on bacterial load during “Root canal treatment (RCT)”.Materials and Methods:In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5% NaOCl as the irrigant, while Group B received 2% CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting “colony-forming units (CFUs)” following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05.Results:Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96% reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86% reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant.Conclusion:Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. ABSTRACT Objective: This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)". Materials and Methods: In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5 NaOCl as the irrigant, while Group B received 2 CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting "colony-forming units (CFUs)" following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05. Results: Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96 reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86 reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant. Conclusion: Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. Keywords: Antimicrobial efficacy, chlorhexidine, endodontic irrigation, root canal therapy, sodium hypochlorite This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their effects on bacterial load during "Root canal treatment (RCT)". In this randomized controlled trial, 80 subjects requiring RCT were included. The participants were randomly allocated into two groups: Group A received 2.5 NaOCl as the irrigant, while Group B received 2 CHX. Microbial samples were gathered from the root canals using sterile paper points both before and after irrigation. The bacterial load was evaluated by counting "colony-forming units (CFUs)" following bacterial culture. Statistical analyzes were conducted using paired t-tests and ANOVA, with a significance level of P < 0.05. Both NaOCl and CHX demonstrated substantial reductions in the bacterial load within the canal system. Group A (NaOCl) achieved a post-irrigation mean CFU count of 1.9 million, reflecting a 96 reduction in bacterial load. Group B (CHX) recorded a mean CFU count of 6.7 million, corresponding to an 86 reduction. The difference in bacterial reduction between the two groups was statistically significant (P < 0.01), indicating that NaOCl was more effective than CHX as an irrigant. Sodium hypochlorite proved to be more efficient than chlorhexidine in reducing microbial counts in root canals. While NaOCl appears to offer superior bacterial reduction, CHX, due to its substantivity and lower cytotoxicity, may still have valuable roles in particular clinical contexts. |
| Audience | Academic |
| Author | Prasad, L Karthik Patel, Panthi Suthar, Mahishi G. Samal, Sweta Mallikarjun, Elaprolu Markan, Sheenam Yaser, Almazyad |
| AuthorAffiliation | 5 Department of Conservative Dental Sciences, Endodontic Division, College of Dentistry, Qassim University, Saudi Arabia 2 Conservative Dentistry and Endodontics, Dental Officer, E.C.H.S Polyclinic, Ropar, Punjab, India 3 Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India 1 Department of Dentistry, ESIC Medical College and Hospital, Sanathnagar, Hyderabad, Telangana, India 7 Ahmedabad Dental College and Hospital, Ahmedabad, Gujarat, India 4 Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Patia, Bhubaneswar, Odisha, India 6 Department of Conservative Dentistry and Endodontics, GSL Dental College, Rajahmundry, Andhra Pradesh, India |
| AuthorAffiliation_xml | – name: 5 Department of Conservative Dental Sciences, Endodontic Division, College of Dentistry, Qassim University, Saudi Arabia – name: 6 Department of Conservative Dentistry and Endodontics, GSL Dental College, Rajahmundry, Andhra Pradesh, India – name: 3 Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India – name: 7 Ahmedabad Dental College and Hospital, Ahmedabad, Gujarat, India – name: 1 Department of Dentistry, ESIC Medical College and Hospital, Sanathnagar, Hyderabad, Telangana, India – name: 2 Conservative Dentistry and Endodontics, Dental Officer, E.C.H.S Polyclinic, Ropar, Punjab, India – name: 4 Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Patia, Bhubaneswar, Odisha, India |
| Author_xml | – sequence: 1 givenname: L Karthik surname: Prasad fullname: Prasad, L Karthik email: drkarthikendo@yahoo.com – sequence: 2 givenname: Sheenam surname: Markan fullname: Markan, Sheenam – sequence: 3 givenname: Mahishi G. surname: Suthar fullname: Suthar, Mahishi G. – sequence: 4 givenname: Sweta surname: Samal fullname: Samal, Sweta – sequence: 5 givenname: Almazyad surname: Yaser fullname: Yaser, Almazyad – sequence: 6 givenname: Elaprolu surname: Mallikarjun fullname: Mallikarjun, Elaprolu – sequence: 7 givenname: Panthi surname: Patel fullname: Patel, Panthi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40511249$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kl1v0zAUhiM0xMbYD-AGReKGmw5_5cNXqOoGqzQJiY1r68QfrbvELnayUn49TruNFYEjJ_bxex77xO_r7Mh5p7PsLUbnDCP6cbVu4vn4EpgRIgh7kZ0gXhWTiqHyaDcuJ6yu-HF2FuMKpUY54Zi-yo4ZKjAmjJ9kv2a-W0OA3t7rfOqg3UYbc2_SuLedlcE3Ftr80hgrQW7HlRuv7NDlV9u1l8vWB9vrHJzKZ-NkqX9aZV2KxHwegl2A62NuXf7N-z6fQdohv13qAOvtm-ylgTbqs4fvafb98-Xt7Gpy_fXLfDa9nsgCsX4iAVOJZEEkYo1BijUSQBnDKsZRU3NuNMGmNowyVNUFRspoVVKEldLIFIaeZvM9V3lYiXWwHYSt8GDFLuDDQkDorWy1aDjQCoOSSuNEM1CQInVWNqBRperE-rRnrYem00pq1wdoD6CHK84uxcLfC0xwUZYlS4QPD4Tgfww69qKzUeq2Baf9EAUluGZVyatR-v4v6coPIf3BUYUIKQtC6R_VAlIF1hmfNpYjVExryhFnjI4HP_-HKj1Kp1tOzjI2xQ8S3j2v9KnER-skAd4LkkdiDNo8STASo0PFzpzPHZpyLvY5G9_2OsS7dtjoIBL_zvnN_xPFDSuYeLQq_Q1_RPO6 |
| Cites_doi | 10.32553/ijmbs.v6i4.2508 10.1111/etp.12031 10.1016/j.joen.2005.09.014 10.1055/s-0041-1736262 10.1016/S1079-2104(03)00360-3 10.1046/j.1365-2591.1997.00096.x 10.1016/j.cden.2009.12.001 10.5005/jp-journals-10024-2939 10.1111/j.1365-2591.1985.tb00416.x |
| ContentType | Journal Article |
| Copyright | 2025 Journal of Pharmacy and Bioallied Sciences Copyright: © 2025 Journal of Pharmacy and Bioallied Sciences. COPYRIGHT 2025 Medknow Publications and Media Pvt. Ltd. 2025. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright: © 2025 Journal of Pharmacy and Bioallied Sciences 2025 |
| Copyright_xml | – notice: 2025 Journal of Pharmacy and Bioallied Sciences – notice: Copyright: © 2025 Journal of Pharmacy and Bioallied Sciences. – notice: COPYRIGHT 2025 Medknow Publications and Media Pvt. Ltd. – notice: 2025. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright: © 2025 Journal of Pharmacy and Bioallied Sciences 2025 |
| DBID | AAYXX CITATION NPM K9. NAPCQ 7X8 5PM DOA |
| DOI | 10.4103/jpbs.jpbs_1422_24 |
| DatabaseName | CrossRef PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 0975-7406 |
| Edition | 2 |
| EndPage | S456 |
| ExternalDocumentID | oai_doaj_org_article_b9a371adcde1407fa525a5246bae07d8 PMC12156664 A839094438 40511249 10_4103_jpbs_jpbs_1422_24 JPBS-17-S454 |
| Genre | Journal Article |
| GeographicLocations | India |
| GeographicLocations_xml | – name: India |
| GroupedDBID | --- 5VS 7RV 7X7 8FE 8FH 8FI 8FJ 8G5 AAFWJ ABDBF ABJNI ABUWG ACGFS ACPRK ACUHS ADBBV ADRAZ AFKRA AFPKN ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ CCPQU DIK DWQXO E3Z EBD EOJEC ESX F5P FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 H13 HCIFZ HMCUK HYE IAO IHR IL9 INH INR IPNFZ ITC KQ8 LK8 M2O M48 M7P MK0 ML0 M~E NAPCQ O5R O5S OBODZ OK1 OVD P2P PGMZT PHGZM PHGZT PIMPY PMFND PQQKQ PROAC RIG RMW RNS RPM TEORI TR2 TUS UKHRP W3E AAYXX ADJBI CITATION NPM K9. 7X8 5PM |
| ID | FETCH-LOGICAL-c504t-ca13c0c52c04bf0d4bcaadff47490b899fe21f8f434078510dfed6301dde0f5f3 |
| IEDL.DBID | M48 |
| ISSN | 0976-4879 |
| IngestDate | Wed Aug 27 01:24:50 EDT 2025 Thu Aug 21 18:24:45 EDT 2025 Fri Jun 13 18:14:30 EDT 2025 Sat Aug 23 13:05:29 EDT 2025 Tue Jun 17 22:00:04 EDT 2025 Tue Jun 10 20:53:48 EDT 2025 Sun Jun 15 01:30:30 EDT 2025 Sun Jul 06 05:06:26 EDT 2025 Wed May 28 22:59:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | Suppl 1 |
| Keywords | Antimicrobial efficacy endodontic irrigation chlorhexidine root canal therapy sodium hypochlorite |
| Language | English |
| License | Copyright: © 2025 Journal of Pharmacy and Bioallied Sciences. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c504t-ca13c0c52c04bf0d4bcaadff47490b899fe21f8f434078510dfed6301dde0f5f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.4103/jpbs.jpbs_1422_24 |
| PMID | 40511249 |
| PQID | 3202265233 |
| PQPubID | 226472 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_b9a371adcde1407fa525a5246bae07d8 pubmedcentral_primary_oai_pubmedcentral_nih_gov_12156664 proquest_miscellaneous_3218476974 proquest_journals_3202265233 gale_infotracmisc_A839094438 gale_infotracacademiconefile_A839094438 pubmed_primary_40511249 crossref_primary_10_4103_jpbs_jpbs_1422_24 wolterskluwer_medknow_10_4103_jpbs_jpbs_1422_24_S454_Comparat |
| PublicationCentury | 2000 |
| PublicationDate | 20250500 |
| PublicationDateYYYYMMDD | 2025-05-01 |
| PublicationDate_xml | – month: 05 year: 2025 text: 20250500 |
| PublicationDecade | 2020 |
| PublicationPlace | India |
| PublicationPlace_xml | – name: India – name: Mumbai |
| PublicationTitle | Journal of pharmacy & bioallied science |
| PublicationTitleAlternate | J Pharm Bioallied Sci |
| PublicationYear | 2025 |
| Publisher | Wolters Kluwer - Medknow Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications |
| Publisher_xml | – name: Wolters Kluwer - Medknow – name: Medknow Publications and Media Pvt. Ltd – name: Medknow Publications & Media Pvt. Ltd – name: Wolters Kluwer Medknow Publications |
| References | Arora (R4-20250513) 2022; 6 Mohammadi (R3-20250513) 2013; 62 Siqueira (R8-20250513) 1997; 30 Srinivasan (R10-20250513) 2020; 21 Haapasalo (R1-20250513) 2010; 54 Basrani (R6-20250513) 2012; 27 Zehnder (R2-20250513) 2006; 32 Vianna (R5-20250513) 2004; 97 Takhar (R9-20250513) 2021; 9 Bystrom (R7-20250513) 1985; 18 |
| References_xml | – volume: 6 start-page: 103 year: 2022 ident: R4-20250513 article-title: Assessment of the color variation of the various nanocomposites:An invitro stud publication-title: Int J Med Biomed Stud doi: 10.32553/ijmbs.v6i4.2508 – volume: 27 start-page: 74 year: 2012 ident: R6-20250513 article-title: Update on endodontic irrigating solutions publication-title: Endod Topics doi: 10.1111/etp.12031 – volume: 32 start-page: 389 year: 2006 ident: R2-20250513 article-title: Root canal irrigants publication-title: J Endod doi: 10.1016/j.joen.2005.09.014 – volume: 9 start-page: 128 year: 2021 ident: R9-20250513 article-title: Comparative evaluation of the effect of different endodontic irrigation protocols on the microhardness of root canal dentin:An in vitro study publication-title: Dent J Adv Stud doi: 10.1055/s-0041-1736262 – volume: 97 start-page: 79 year: 2004 ident: R5-20250513 article-title: In vitro evaluation of the antimicrobial activity of chlorhexidine and sodium hypochlorite publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod doi: 10.1016/S1079-2104(03)00360-3 – volume: 62 start-page: 28 year: 2013 ident: R3-20250513 article-title: Antimicrobial activity of sodium hypochlorite in endodontics publication-title: J Mass Dent Soc – volume: 30 start-page: 279 year: 1997 ident: R8-20250513 article-title: Evaluation of the effectiveness of sodium hypochlorite used with three irrigation methods in the elimination of Enterococcus faecalis from the root canal, in vitro publication-title: Int Endod J doi: 10.1046/j.1365-2591.1997.00096.x – volume: 54 start-page: 291 year: 2010 ident: R1-20250513 article-title: Irrigation in endodontics publication-title: Dent Clin North Am doi: 10.1016/j.cden.2009.12.001 – volume: 21 start-page: 1325 year: 2020 ident: R10-20250513 article-title: Comparative study of antifungal efficacy of various endodontic irrigants with and without clotrimazole in extracted teeth inoculated with Candida albicans publication-title: J Contemp Dent Pract doi: 10.5005/jp-journals-10024-2939 – volume: 18 start-page: 35 year: 1985 ident: R7-20250513 article-title: The antibacterial action of sodium hypochlorite and EDTA in 60 cases of endodontic therapy publication-title: Int Endod J doi: 10.1111/j.1365-2591.1985.tb00416.x |
| SSID | ssj0000392913 |
| Score | 2.3340385 |
| Snippet | ABSTRACT
Objective:
This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants,... This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants, evaluating their... ABSTRACT Objective: This research aims to analyze the antimicrobial efficacy of "sodium hypochlorite (NaOCl)" and "chlorhexidine (CHX)" as canal irrigants,... ABSTRACTObjective:This research aims to analyze the antimicrobial efficacy of “sodium hypochlorite (NaOCl)” and “chlorhexidine (CHX)” as canal irrigants,... Objective: This research aims to analyze the antimicrobial efficacy of “sodium hypochlorite (NaOCl)” and “chlorhexidine (CHX)” as canal irrigants, evaluating... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref wolterskluwer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | S454 |
| SubjectTerms | Analysis antimicrobial efficacy Chlorhexidine Comparative analysis Cytotoxicity endodontic irrigation Endodontics Ethylenediaminetetraacetic acid Lavage Microorganisms Original Research Root canal therapy Root canals Sodium hypochlorite Statistical analysis |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9MwFLfQTkgI8U1hICOhIaGFOYmdNAcOo9pUkEAT26TdrPhrDdCkalJB-et5z0nbBIS4cGjVxo4V-33Hz79HyMtMR2BWNAtSnouAp0kW5EbrgDGlHEhmkvhTaR8_JdNL_uFKXPVKfWFOWAsP3C7ckcryOA3hfmMhFkhdLiIBH56o3LLU-GO-YPN6wZTXwWj229rIYG8D8MqzdkuThyw--rJQ9Rv8kvgGREZ8YJQ8dv-fGrpnon5Pn7z1vcKt7fqrz2zv2afTO-R251jS43ZCd8kNW94jB2ctMvX6kF7sDlrVh_SAnu0wq9f3yc_JDgWcboBKaOXgd1PMC4_WBKOfIOAEDIct55UpVnM6XS8qPcM8vsbSvDR0gn9m9kcBVhGu1PT9cllcY7oNLUr6uaoaipAI37onWj8gl6cnF5Np0JVlCLRgvAl0HsaaaRFpxpVjhiud58Y5nvKMKYjfnI1CN3Y8xj1CkHnjrElAkYAmZU64-CHZK6vSPiZUaHyhGaepcIoby4HYNhwbK2xiHIujEXm9oYtctOgbEqIWJKL09OsTcUTeIeW2HRE4218AdpIdO8l_sdOIvEK6SxRvIC4saXtKAZ4XgbLkMTiUEBHzGHruD3qCWOph84ZzZKcWaonF6qMEYv94RF5sm_FOTHUrbbXCPhB0g8ykMKFHLaNtpwTedYjVwkdkPGDBwZyHLWUx86DhiCICkgeDvh1wq5y3xy7_vq7ynAsuN2z45H-s8lNyM8I6yj5xdJ_sNcuVfQbOXaOeezn-BapKUTw priority: 102 providerName: Directory of Open Access Journals – databaseName: Medknow Open Access Journals dbid: W3E link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagXJBQxZuUgoyEioQa6sR2vDlwKKtWCxKooq3Um5X4oQ2wyarJCpZfz0ySfYTHicNGm9hx4syMZ8ae-UzIy9TEoFYMC5XIZChUkoaZNSZkLM89SGaStFlpHz8lk0vx4Upe9WDRmAuztX4vIsaPvszz-g0eNE5W6FjcJLdiBXyGySN8M53CUM93myGDgg3BDE-7Ncy_tzLQQi1Y_59D8pZO-j1e8s73Ctey669tKPuWQjq9S3Z7S5Ied6S_R2648j45OOugqJeH9GKTWVUf0gN6tgGpXj4gP8cb2G-6QiahlYf_TTErWngmaP0EESagOSw5r2yxmNHJcl6ZKQbuNY5mpaVjPJm6HwWoQbhS0_fX4PJjfA0tSvq5qhqKGAjf-jdaPiSXpycX40nY78MQGslEE5os4oYZGRsmcs-syE2WWe-FEinLwWHzLo78yAuOi4Ig5NY7m8DIAUMn89LzR2SnrEr3hFBpcAaTKyV9LqwTeZq5aGSddIn1jMcBeb2ii553cBsa3BQkom7pt03EgLxDyq0rIlJ2ewEYSPeCp-EJXEXAf9aBL6l8JmMJP5HkmWPKjgLyCumuUZ6BuPBJu7QEeF9ExtLHYEGCCyw41Nwf1AQ5NMPiFefofhyoNe5OHyfg7POAvFgX450Y21a6aoF1wMsGIVHQoccdo627BOZ0hNuDB2Q0YMFBn4clZTFtUcIRNgREDRp9O-BWPevyLP_9XfW5kEKv2HDvP-9_Sm7HuGdyGyS6T3aa64V7BoZckz9vRfgXqjhKrw priority: 102 providerName: Wolters Kluwer Health |
| Title | Comparative Analysis of Antimicrobial Efficacy of Sodium Hypochlorite and Chlorhexidine as Irrigants in Root Canal Therapy |
| URI | https://doi.org/10.4103/jpbs.jpbs_1422_24 https://www.ncbi.nlm.nih.gov/pubmed/40511249 https://www.proquest.com/docview/3202265233 https://www.proquest.com/docview/3218476974 https://pubmed.ncbi.nlm.nih.gov/PMC12156664 https://doaj.org/article/b9a371adcde1407fa525a5246bae07d8 |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfGeEFCiG8CYzISGhJaipPYSfuA0Kg6CtLQxFbRNyvxxxpYk9KmYuWv5y4fbQPjhYdabew6ce7Od2eff0fIy57yQa0o5kY8Fi6Pwp4ba6VcxpLEgmSGYXkq7eRzOBzxT2Mx3iFNeqv6BS6ude0wn9Roftm5-rF6BwIP9muHeyx4822WLDpYSFzQkD6_QW6CYoowk8NJbe2XEzPaAlXCZFDCLpjqvWqf8_peWpqqBPT_e9re0lt_xlTe_pnjfvfiexnuvqW0ju-SO7W1SY8q9rhHdkx2nxycVnDVq0N6vjl9tTikB_R0A2S9ekB-9TfQ4LRBL6G5he9FOk1LCCfofYAoFNAd1pzlOl1O6XA1y9UEg_sKQ-NM0z7-mJirFFQlXFnQj_N5eoExODTN6Jc8LyjiJFzWT7R6SEbHg_P-0K1zNbhKMF64KvYCxZTwFeOJZZonKo61tTziPZaAU2eN79mu5QFuHMJEoK3RIcwuML0yK2zwiOxmeWaeECoUrnIGUSRswrXhSS82XlcbYUJtWeA75HVDFzmrIDkkuDJIRFnSb5uIDnmPlFs3RDTt8kI-v5C1cEq4QxB5wKPagL8Z2Vj4Aj48TGLDIt11yCuku0QuBOLCK62OLsDzInqWPAIrE9xkHkDLvVZLkFXVrm44RzasLjGDvR8KPwgc8mJdjf_E-LfM5EtsA544CFIEA3pcMdp6SGBye5hC3CHdFgu2xtyuydJJiSSO0CIgjtDp2xa3yml1FvPf71WeccFlw4ZP___Wz8gtH1MqlzGke2S3mC_Nc7DzimS_XB-B8sPY2y8lGcqvweA3wh5beA |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparative+Analysis+of+Antimicrobial+Efficacy+of+Sodium+Hypochlorite+and+Chlorhexidine+as+Irrigants+in+Root+Canal+Therapy&rft.jtitle=Journal+of+pharmacy+%26+bioallied+science&rft.au=Prasad%2C+L+Karthik&rft.au=Markan%2C+Sheenam&rft.au=Suthar%2C+Mahishi+G.&rft.au=Samal%2C+Sweta&rft.date=2025-05-01&rft.pub=Wolters+Kluwer+-+Medknow&rft.issn=0976-4879&rft.eissn=0975-7406&rft.volume=17&rft.issue=Suppl+1&rft.spage=S454&rft.epage=S456&rft_id=info:doi/10.4103%2Fjpbs.jpbs_1422_24&rft.externalDocID=PMC12156664 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0976-4879&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0976-4879&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0976-4879&client=summon |