Objective measurement of gait parameters in healthy and cognitively impaired elderly using the dual-task paradigm

• Published in: Aging clinical and experimental research Vol. 29; no. 6; pp. 1181 - 1189
• Main Authors: König, Alexandra, Klaming, Laura, Pijl, Marten, Demeurraux, Alexandre, David, Renaud, Robert, Philippe
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2017; Springer Nature B.V; Springer Verlag
• Subjects: Accelerometry - methods; Aged; Aged, 80 and over; Alzheimer Disease - physiopathology; Alzheimer Disease - psychology; Case-Control Studies; Cognitive ability; Cognitive Dysfunction - physiopathology; Cognitive Dysfunction - psychology; Computation and Language; Computer Science; Dementia; Disease Progression; Female; Gait; Geriatrics/Gerontology; Health Status; Humans; Male; Medicine; Medicine & Public Health; Mental Status and Dementia Tests; Original; Original Article; Walking Speed - physiology; Gait; Mild cognitive impairment; Attention; Actigraphy; Accelerometer; Dual-task; Motor function; Alzheimer; Dementia
• ISSN: 1720-8319; 1594-0667; 1720-8319
• DOI: 10.1007/s40520-016-0703-6

Objectives The present study explores the differences in gait parameters in elderly subjects with or without cognitive impairment measured by means of ambulatory actigraphy while performing a single and a dual task. Methods Sixty-nine participants of which 23 individuals were diagnosed with Alzheimer’s disease (AD), 24 individuals with mild cognitive impairment (MCI), and 22 healthy controls performed a single and dual walking task while wearing a wrist-worn accelerometer. Objective measures of gait features such as walking speed, cadence (i.e., number of steps per minute), and step variance (i.e., variance in time between two consecutive steps) were derived and analyzed. Results While differences in several gait parameters, namely walking speed, were found between MCI and AD patients, no differences between healthy elderly and MCI patients were found. Conclusion Walking speed seems to be a gait-related feature that differs significantly between MCI and AD patients and thus could be used as an additional measurement in clinical assessment. However, differences in gait may not be salient enough in the early stages of dementia to be detected by actigraphy. More research comparing different methods to measure gait in early stages of dementia under different dual task conditions is neccessary.