Polymorphisms in DNA Base Excision Repair Genes ADPRT and XRCC1 and Risk of Lung Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 65; no. 3; pp. 722 - 726
• Main Authors: Zhang, Xuemei, Miao, Xiaoping, Liang, Gang, Hao, Bingtao, Wang, Yonggang, Tan, Wen, Li, Yi, Guo, Yongli, He, Fuchu, Wei, Qingyi, Lin, Dongxin
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.02.2005
• Subjects: Aged; Antineoplastic agents; Biological and medical sciences; Case-Control Studies; DNA Repair - genetics; DNA-Binding Proteins - genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms - genetics; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Pneumology; Poly(ADP-ribose) Polymerases - genetics; Polymorphism, Genetic; Smoking - adverse effects; Smoking - genetics; Tumors of the respiratory system and mediastinum; X-ray Repair Cross Complementing Protein 1; Lung disease; Genetic variability; Excision; Respiratory disease; Lung cancer; DNA; Risk factor; Genotype; DNA repair; Bronchopulmonary; Repair gene; Polymorphism

Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are two major DNA base excision repair (BER) proteins and act interactively in stimulating and executing BER processes. Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Gln have been associated with alte...