Effects of a Self–micro-emulsifying Delivery System Formulation Versus a Standard ω-3 Acid Ethyl Ester Product on the Bioavailability of Eicosapentaenoic Acid and Docosahexaenoic Acid: A Study in Healthy Men and Women in a Fasted State

• Published in: Clinical therapeutics Vol. 40; no. 12; pp. 2065 - 2076
• Main Authors: Maki, Kevin C., Palacios, Orsolya M., Buggia, Mary A., Trivedi, Rupal, Dicklin, Mary R., Maki, Cathleen E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018; Elsevier Limited
• Subjects: Alcohol; Bioavailability; Blood & organ donations; Blood pressure; Body mass index; Clinical trials; Dietary supplements; Docosahexaenoic acid; Drug dosages; Eicosapentaenoic acid; Family medical history; Fasting; Fatty acids; Fish oils; Hispanic Americans; Laboratories; Mathematics; Smoking; Women; ω-3 self–micro-emulsifying delivery system; ω-3 self–micro-emulsifying delivery system; eicosapentaenoic acid; fish oils; bioavailability; docosahexaenoic acid

Intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with several potential health benefits, but standard ethyl ester (EE) formulations of these ω-3 fatty acids require the co-ingestion of fat for adequate absorption. The objective of this research was to assess the r...