Identification of consensus biomarkers for predicting non-genotoxic hepatocarcinogens

• Published in: Scientific reports Vol. 7; no. 1; p. 41176
• Main Authors: Huang, Shan-Han, Tung, Chun-Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.01.2017; Nature Publishing Group
• Subjects: 38; 45; 631/114/1305; 631/114/2164; 631/114/2407; 631/114/2413; Animal models; Bioassays; Biomarkers; Chemicals; Decision trees; Genotoxicity; Humanities and Social Sciences; Learning algorithms; multidisciplinary; Prediction models; Risk assessment; Science

The assessment of non-genotoxic hepatocarcinogens (NGHCs) is currently relying on two-year rodent bioassays. Toxicogenomics biomarkers provide a potential alternative method for the prioritization of NGHCs that could be useful for risk assessment. However, previous studies using inconsistently class...