A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process

• Published in: Scientific reports Vol. 6; no. 1; p. 25022
• Main Authors: An, Fan, Qu, Yueyang, Luo, Yong, Fang, Ning, Liu, Yang, Gao, Zhigang, Zhao, Weijie, Lin, Bingcheng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.04.2016; Nature Publishing Group
• Subjects: 631/154/1435; 692/700/139; Animal research; Antitumor agents; Candidates; Cell culture; Cell Line; Clinical trials; Dialysis; Drug development; Drug discovery; Drug Evaluation, Preclinical - instrumentation; Drug Evaluation, Preclinical - methods; Drug metabolism; Hepatotoxicity; Humanities and Social Sciences; Humans; Lab-On-A-Chip Devices; Membranes; Microfluidics; Molecular weight; multidisciplinary; Pharmacokinetics; Science; Sodium

New techniques are urgently needed to replace conventional long and costly pre-clinical testing in the new drug administration process. In this study, a laminated microfluidic device was fabricated to mimic the drug ADME response test in vivo . This proposed device was loaded and cultured with funct...