Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis

• Published in: Scientific reports Vol. 7; no. 1; p. 40252
• Main Authors: Loewe, Kristian, Machts, Judith, Kaufmann, Jörn, Petri, Susanne, Heinze, Hans-Jochen, Borgelt, Christian, Harris, Joseph Allen, Vielhaber, Stefan, Schoenfeld, Mircea Ariel
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.01.2017; Nature Publishing Group
• Subjects: 59; 59/36; 631/378/1689/1285; 692/617/375/1917/1285; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - physiopathology; Brain; Brain Mapping; Dementia disorders; Female; Frontotemporal dementia; Functional magnetic resonance imaging; Humanities and Social Sciences; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor task performance; multidisciplinary; Neural networks; Neurodegeneration; Neuroimaging; Neuropsychological Tests; Occipital lobe; Occipital Lobe - physiopathology; Science; Science (multidisciplinary); Temporal lobe; Temporal Lobe - physiopathology

Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in...