Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis

Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in...

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Published in	Scientific reports Vol. 7; no. 1; p. 40252
Main Authors	Loewe, Kristian, Machts, Judith, Kaufmann, Jörn, Petri, Susanne, Heinze, Hans-Jochen, Borgelt, Christian, Harris, Joseph Allen, Vielhaber, Stefan, Schoenfeld, Mircea Ariel
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 09.01.2017 Nature Publishing Group
Subjects	59 59/36 631/378/1689/1285 692/617/375/1917/1285 Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - physiopathology Brain Brain Mapping Dementia disorders Female Frontotemporal dementia Functional magnetic resonance imaging Humanities and Social Sciences Humans Magnetic Resonance Imaging Male Middle Aged Motor task performance multidisciplinary Neural networks Neurodegeneration Neuroimaging Neuropsychological Tests Occipital lobe Occipital Lobe - physiopathology Science Science (multidisciplinary) Temporal lobe Temporal Lobe - physiopathology
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Abstract	Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in ALS, the present study aimed to examine changes in functional connectivity across the whole brain, particularly with regard to extra-motor regions, in a group of 64 non-demented ALS patients and 38 healthy controls. To assess between-group differences in connectivity, we computed edge-level statistics across subject-specific graphs derived from resting-state functional MRI data. In addition to expected ALS-related decreases in functional connectivity in motor-related areas, we observed extensive changes in connectivity across the temporo-occipital cortex. Although ALS patients with comorbid FTD were deliberately excluded from this study, the pattern of connectivity alterations closely resembles patterns of cerebral degeneration typically seen in FTD. This evidence for subclinical temporal dysfunction supports the idea of a common pathology in ALS and FTD.
AbstractList	Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in ALS, the present study aimed to examine changes in functional connectivity across the whole brain, particularly with regard to extra-motor regions, in a group of 64 non-demented ALS patients and 38 healthy controls. To assess between-group differences in connectivity, we computed edge-level statistics across subject-specific graphs derived from resting-state functional MRI data. In addition to expected ALS-related decreases in functional connectivity in motor-related areas, we observed extensive changes in connectivity across the temporo-occipital cortex. Although ALS patients with comorbid FTD were deliberately excluded from this study, the pattern of connectivity alterations closely resembles patterns of cerebral degeneration typically seen in FTD. This evidence for subclinical temporal dysfunction supports the idea of a common pathology in ALS and FTD. Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in ALS, the present study aimed to examine changes in functional connectivity across the whole brain, particularly with regard to extra-motor regions, in a group of 64 non-demented ALS patients and 38 healthy controls. To assess between-group differences in connectivity, we computed edge-level statistics across subject-specific graphs derived from resting-state functional MRI data. In addition to expected ALS-related decreases in functional connectivity in motor-related areas, we observed extensive changes in connectivity across the temporo-occipital cortex. Although ALS patients with comorbid FTD were deliberately excluded from this study, the pattern of connectivity alterations closely resembles patterns of cerebral degeneration typically seen in FTD. This evidence for subclinical temporal dysfunction supports the idea of a common pathology in ALS and FTD.Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in ALS, the present study aimed to examine changes in functional connectivity across the whole brain, particularly with regard to extra-motor regions, in a group of 64 non-demented ALS patients and 38 healthy controls. To assess between-group differences in connectivity, we computed edge-level statistics across subject-specific graphs derived from resting-state functional MRI data. In addition to expected ALS-related decreases in functional connectivity in motor-related areas, we observed extensive changes in connectivity across the temporo-occipital cortex. Although ALS patients with comorbid FTD were deliberately excluded from this study, the pattern of connectivity alterations closely resembles patterns of cerebral degeneration typically seen in FTD. This evidence for subclinical temporal dysfunction supports the idea of a common pathology in ALS and FTD.
ArticleNumber	40252
Author	Vielhaber, Stefan Harris, Joseph Allen Schoenfeld, Mircea Ariel Loewe, Kristian Petri, Susanne Kaufmann, Jörn Machts, Judith Heinze, Hans-Jochen Borgelt, Christian
Author_xml	– sequence: 1 givenname: Kristian surname: Loewe fullname: Loewe, Kristian email: kristian.loewe@med.ovgu.de organization: Department of Neurology, Otto-von-Guericke University, Department of Computer Science, Otto-von-Guericke University – sequence: 2 givenname: Judith surname: Machts fullname: Machts, Judith organization: Department of Neurology, Otto-von-Guericke University, German Center for Neurodegenerative Diseases (DZNE) – sequence: 3 givenname: Jörn surname: Kaufmann fullname: Kaufmann, Jörn organization: Department of Neurology, Otto-von-Guericke University – sequence: 4 givenname: Susanne surname: Petri fullname: Petri, Susanne organization: Department of Neurology, Hannover Medical School – sequence: 5 givenname: Hans-Jochen surname: Heinze fullname: Heinze, Hans-Jochen organization: Department of Neurology, Otto-von-Guericke University, German Center for Neurodegenerative Diseases (DZNE), Leibniz Institute for Neurobiology – sequence: 6 givenname: Christian surname: Borgelt fullname: Borgelt, Christian organization: Department of Computer Science, Otto-von-Guericke University – sequence: 7 givenname: Joseph Allen surname: Harris fullname: Harris, Joseph Allen organization: Department of Neurology, Otto-von-Guericke University – sequence: 8 givenname: Stefan surname: Vielhaber fullname: Vielhaber, Stefan organization: Department of Neurology, Otto-von-Guericke University, German Center for Neurodegenerative Diseases (DZNE) – sequence: 9 givenname: Mircea Ariel surname: Schoenfeld fullname: Schoenfeld, Mircea Ariel organization: Department of Neurology, Otto-von-Guericke University, Leibniz Institute for Neurobiology, Kliniken Schmieder Heidelberg, Speyererhofweg 1, 69117 Heidelberg, Germany
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28067298$$D View this record in MEDLINE/PubMed
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Snippet	Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous...
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StartPage	40252
SubjectTerms	59 59/36 631/378/1689/1285 692/617/375/1917/1285 Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - physiopathology Brain Brain Mapping Dementia disorders Female Frontotemporal dementia Functional magnetic resonance imaging Humanities and Social Sciences Humans Magnetic Resonance Imaging Male Middle Aged Motor task performance multidisciplinary Neural networks Neurodegeneration Neuroimaging Neuropsychological Tests Occipital lobe Occipital Lobe - physiopathology Science Science (multidisciplinary) Temporal lobe Temporal Lobe - physiopathology
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Title	Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis
URI	https://link.springer.com/article/10.1038/srep40252 https://www.ncbi.nlm.nih.gov/pubmed/28067298 https://www.proquest.com/docview/1899501648 https://www.proquest.com/docview/1856866368 https://pubmed.ncbi.nlm.nih.gov/PMC5220336
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